Galactoside O-acetyltransferase
| Galactoside O-acetyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.3.1.18 | ||||||||
| CAS no. | 9029-94-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
| Thiogalactoside acetyltransferase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | lacA | ||||||
| Entrez | 945674 | ||||||
| RefSeq (Prot) | NP_414876 | ||||||
| UniProt | P07464 | ||||||
| |||||||
Galactoside O-acetyltransferase (also known as thiogalactoside transacetylase) is an enzyme encoded by the lacA gene in E. coli. The protein plays a role in cell detoxification.[1]
Reaction
It catalyzes the following reaction:
acetyl-CoA + beta-D-galactoside → CoA + 6-acetyl-beta-D-galactoside
Structure
In E. coli, thiogalactoside transacetylase is a dimer. Its monomer consists of 202 amino acid residues. The protein has a molecular weight of 22,671.[2]
The amino terminus of the protein is heterogenous because the initiator methionine is only partially cleaved. The protein is found in the cell cytoplasm and contains a highly hydrophobic segment in its center.
See also
References
- ^ "Thiogalactoside transacetylase of the lactose operon as an enzyme for detoxification". 1976.
{{cite journal}}: Cite journal requires|journal=(help) - ^ "The amino acid sequence of thiogalactoside transacetylase of Escherichia coli". Biochimie. 67 (1): 101–8. 1985. doi:10.1016/s0300-9084(85)80235-2. PMID 3922433.