Gentisate decarboxylase

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gentisate decarboxylase
Identifiers
EC number 4.1.1.62
CAS number 37290-54-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a gentisate decarboxylase (EC 4.1.1.62) is an enzyme that catalyzes the chemical reaction

2,5-dihydroxybenzoate hydroquinone + CO2

Hence, this enzyme has one substrate, 2,5-dihydroxybenzoate, and two products, hydroquinone and CO2.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2,5-dihydroxybenzoate carboxy-lyase (hydroquinone-forming). Other names in common use include 2,5-dihydroxybenzoate decarboxylase, and gentisate carboxy-lyase. This enzyme participates in tyrosine metabolism.

References[edit]

  • Grant DJW; Patel JC (1969). "Non-oxidative decarboxylation of p-hydroxybenzoic acid, gentisic acid, protocatechuic acid, and gallic acid by Klebsiella aerogenes (Aerobacter aerogenes)". J. Microbiol. Serol. 35: 325–343.