Geranyl diphosphate 2-C-methyltransferase
| Geranyl diphosphate 2-C-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.255 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Geranyl diphosphate 2-C-methyltransferase (EC 2.1.1.255, SCO7701, GPP methyltransferase, GPPMT, 2-methyl-GPP synthase, MGPPS, geranyl pyrophosphate methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:geranyl-diphosphate 2-C-methyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- S-adenosyl-L-methionine + geranyl diphosphate S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate
This enzyme takes part in synthesis of 2-methylisoborneol.
References
- ^ Wang, C.M.; Cane, D.E. (2008). "Biochemistry and molecular genetics of the biosynthesis of the earthy odorant methylisoborneol in Streptomyces coelicolor". J. Am. Chem. Soc. 130: 8908–8909. doi:10.1021/ja803639g. PMID 18563898.
- ^ Ariyawutthiphan, O.; Ose, T.; Tsuda, M.; Gao, Y.; Yao, M.; Minami, A.; Oikawa, H.; Tanaka, I. (2011). "Crystallization and preliminary X-ray crystallographic study of a methyltransferase involved in 2-methylisoborneol biosynthesis in Streptomyces lasaliensis". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 67: 417–420. doi:10.1107/s1744309110051523. PMID 21393856.
- ^ Komatsu, M.; Tsuda, M.; Omura, S.; Oikawa, H.; Ikeda, H. (2008). "Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol". Proc. Natl. Acad. Sci. USA. 105: 7422–7427. doi:10.1073/pnas.0802312105. PMID 18492804.
- ^ Giglio, S.; Chou, W.K.; Ikeda, H.; Cane, D.E.; Monis, P.T. (2011). "Biosynthesis of 2-methylisoborneol in cyanobacteria". Environ. Sci. Technol. 45: 992–998. doi:10.1021/es102992p. PMID 21174459.
External links
- Geranyl+diphosphate+2-C-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)