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Protein HBD PDB 1a00.png
Available structures
PDB Human UniProt search: PDBe RCSB
Aliases HBD, hemoglobin subunit delta
External IDs HomoloGene: 128037 GeneCards: HBD
Gene location (Human)
Chromosome 11 (human)
Chr. Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for HBD
Genomic location for HBD
Band 11p15.4 Start 5,232,678 bp[1]
End 5,235,370 bp[1]
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 11: 5.23 – 5.24 Mb n/a
PubMed search [2] n/a
View/Edit Human

Hemoglobin subunit delta is a protein that in humans is encoded by the HBD gene.[3]


The delta (HBD) and beta (HBB) genes are normally expressed in the adult: two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin. Two alpha chains plus two delta chains constitute HbA2, which with HbF comprises the remaining 3% of adult hemoglobin. Five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5' - epsilongamma-Ggamma-Adeltabeta - 3'.[4]

Clinical significance[edit]

Mutations in the delta-globin gene are associated with Delta-thalassemia.[4]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000223609 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". 
  3. ^ Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (May 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood. 73 (5): 1081–104. PMID 2649166. 
  4. ^ a b "Entrez Gene: HBD hemoglobin, delta". 

Further reading[edit]

  • Schillirò G, Russo-Mancuso G, Dibenedetto SP, et al. (1992). "Six rare hemoglobin variants found in Sicily". Hemoglobin. 15 (5): 431–7. doi:10.3109/03630269108998862. PMID 1802885. 
  • Collins FS, Weissman SM (1985). "The molecular genetics of human hemoglobin". Prog. Nucleic Acid Res. Mol. Biol. 31: 315–462. PMID 6397774. 
  • Giardina B, Messana I, Scatena R, Castagnola M (1995). "The multiple functions of hemoglobin". Crit. Rev. Biochem. Mol. Biol. 30 (3): 165–96. doi:10.3109/10409239509085142. PMID 7555018.