HLA-B18




major histocompatibility complex (human), class I, B18
Alleles	B*1801
Alleles	B*1802
Alleles	B*1803
Structure (See HLA-B)
Symbol(s)	HLA-B
EBI-HLA	B*1801
EBI-HLA	B*1802
EBI-HLA	B*1803
Locus	chr.6 6p21.31

HLA-B18 (B18) is an HLA-B serotype. The serotype identifies the more common HLA-B*18 gene products.^[1] (For terminology help see: HLA-serotype tutorial) B*1801, the most common allele is at highest frequencies in Northern Italy and the Balkans, a peak frequency distribution it shares with B*3501.

Serotype

B18 serotype recognition of Some HLA B*18 allele-group gene products^[2]
B*18	B18		Sample
allele	%	%	size (N)
1801	96		1641
1802	90		31
1803	83		29

Allele frequencies

**HLA B*1801 frequencies**
		freq
ref.	Population	(%)
^[3]	Italy North pop 1	16.7
^[3]	Croatia	11.3
^[3]	Georgia Svaneti Svans	11.3
^[3]	Romanian	11.3
^[3]	Portugal South	11.2
^[3]	Singapore Riau Malay	9.9
^[3]	Bulgaria	9.1
^[3]	Israel Arab Druse	8.5
^[3]	Azores Central Islands	8.0
^[3]	Portugal Centre	8.0
^[3]	Finland	7.8
^[3]	Azores Santa Maria and Sao Miguel	7.7
^[3]	Czech Republic	7.5
^[3]	India Jalpaiguri Toto	7.5
^[3]	Iran Baloch	7.1
^[3]	Philippines Ivatan	7.0
^[3]	Thailand	6.7
^[3]	Tunisia	6.7
^[3]	Portugal North	6.5
^[3]	Zimbabwe Harare Shona	6.4
^[3]	Madeira	6.2
^[3]	Mexico Mestizos	6.1
^[3]	Kenya	5.9
^[3]	Belgium	5.1
^[3]	Morocco Nador Metalsa Class I	5.1
^[3]	Singapore Javanese Indonesians	5.1
^[3]	Israel Ashkenazi and Non Ashkenazi Jews	5.0
^[3]	Uganda Kampala	5.0
^[3]	Kenya Nandi	4.8
^[3]	Oman	4.7
^[3]	Georgia Tibilisi Georgians	4.6
^[3]	Bulgaria Gipsy	4.5
^[3]	France South East	4.3
^[3]	Kenya Luo	4.3
^[3]	Ireland South	4.2
^[3]	Russia Arkhangelsk Pomors	4.0
^[3]	Azores Terceira Island	3.9
^[3]	Guinea Bissau	3.8
^[3]	India New Delhi	3.8
^[3]	Spain Eastern Andalusia Gipsy	3.5
^[3]	Australia New South Wales	3.4
^[3]	Georgia Tibilisi Kurds	3.4
^[3]	Zambia Lusaka	3.4
^[3]	Cameroon Yaounde	2.7
^[3]	Senegal Niokholo Mandenka	2.7
^[3]	Cameroon Beti	2.3
^[3]	Ivory Coast Akan Adiopodoume	2.3
^[3]	Sudanese	2.3
^[3]	Saudi Arabia Guraiat and Hail	2.2
^[3]	South African Natal Zulu	2.0
^[3]	Thailand	2.0
^[3]	India Mumbai Marathas	1.9
^[3]	New Caledonia	1.9
^[3]	Papua New Guinea Wanigela	1.5
^[3]	Cameroon Bamileke	1.3

References

^ Marsh SG; Albert ED; Bodmer WF; et al. (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens. 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
^ derived from IMGT/HLA
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ ^o ^p ^q ^r ^s ^t ^u ^v ^w ^x ^y ^z ^aa ^ab ^ac ^ad ^ae ^af ^ag ^ah ^ai ^aj ^ak ^al ^am ^an ^ao ^ap ^aq ^ar ^as ^at ^au ^av ^aw ^ax ^ay ^az ^ba ^bb ^bc Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660. {{cite journal}}: External link in |title= (help)

[pmid15787720-1] Marsh SG; Albert ED; Bodmer WF; et al. (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens. 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

[2] rived from IMGT/HLA

[pmid12753660-3] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ ^o ^p ^q ^r ^s ^t ^u ^v ^w ^x ^y ^z ^aa ^ab ^ac ^ad ^ae ^af ^ag ^ah ^ai ^aj ^ak ^al ^am ^an ^ao ^ap ^aq ^ar ^as ^at ^au ^av ^aw ^ax ^ay ^az ^ba ^bb ^bc Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660. {{cite journal}}: External link in |title= (help)

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