HLA-B45
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| HLA-B (alpha)-β2MG with bound peptide | ||
major histocompatibility complex (human), class I, B45
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| Alleles | B*4501, 4502 . . | |
| Structure (See HLA-B) | ||
| Shared data | ||
| Locus | chr.6 6p21.31 | |
HLA-B45 (B45) is an HLA-B serotype. The serotype identifies the B*45 gene-allele protein products of HLA-B.[1]
B45 is a split antigen of the broad antigen B12, and is a sister type of B44. Gene products of 45 not 44
Serotype
[edit]| B*45 | B45 | B12 | B45 | Sample |
| allele | % | % | % | size (N) |
| *4501 | 93 | 1 | 1 | 2307 |
| *4502 | 75 | 4 | ||
| Alleles link-out to IMGT/HLA Databease at EBI | ||||
Alleles
[edit]It was reported that a novel haplotype was found in Italian bone marrow donors. A2-CW*1601-B45- DRB1*1101-DRB3*0301-DQA1*0102-DQB1*0502. This haplotype indicates possible very recent ancestry from Africa, with the Cw*1601 and B45 components and also with the DR11-DQ5.2 component both extremely rare in Europe.[3]
References
[edit]- ^ Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
- ^ derived from IMGT/HLA
- ^ Daielli C, Salvaneschi L, Ghidini G, Ambroselli F, Gatti C, Martinetti M (April 1996). "A novel Italian haplotype predominates in HLA-B45-positive bone marrow donors: HLA-A2, CW*1601, B45, DRB1*1101, DRB3*0301, DQA1*0102, DQB1*0502". Tissue Antigens. 47 (4): 341–3. doi:10.1111/j.1399-0039.1996.tb02564.x. PMID 8773326.