HLA-B49

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major histocompatibility complex (human), class I, B49
Alleles B*4901, B*4902, B*4903
Structure (See HLA-B)
Symbol(s) HLA-B
EBI-HLA B*4901
B*4902
B*4903
Locus chr.6 6p21.31

HLA-B49 (B49) is an HLA-B serotype. B49 is a split antigen from the B21 broad antigen, the sister serotype B50.[1] The serotype identifies the more common HLA-B*50 gene products.[2] (For terminology help see: HLA-serotype tutorial)

Serotype[edit]

B49 and B21 serotype recognition of some more common HLA B*49 alleles[3]
B*49 B49 B21 Sample
allele  %  % size (N)
4901 94 1 3002

Allele distribution[edit]

HLA B*4901 frequencies
freq
ref. Population (%)
[4] Portugal North 8.7
[4] Spain Basque Gipuzkoa Province 6.1
[4] Madeira 5.9
[4] Cameroon Yaounde 5.4
[4] Morocco Nador Metalsa (Berber) 5.1
[4] Kenya Nandi 4.6
[4] Sudanese 4.3
[4] Portugal South 4.1
[4] Tunisia Tunis 4.0
[4] India Jalpaiguri Toto 3.8
[4] Senegal Niokholo Mandenka 3.7
[4] Uganda Kampala 3.7
[4] Spain Eastern Andalusia 3.5
[4] Tunisia 3.5
[4] Georgia Tibilisi Kurds 3.4
[4] Spain Catalonia Girona 3.4
[4] Italy North (1) 3.3
[4] Cameroon Beti 3.2
[4] Israel Ashkenazi and Non Ashkenazi Jews 3.2
[4] Guinea Bissau 3.1
[4] France South East 2.7
[4] Israel Arab Druse 2.5
[4] Mali Bandiagara 2.5
[4] Jordan Amman 2.4
[4] Tunisia Ghannouch 2.4
[4] Georgia Tibilisi Georgians 2.3
[4] Saudi Arabia Guraiat and Hail 2.2
[4] Cameroon Bamileke 1.9
[4] Czech Republic 1.9
[4] Georgia Svaneti Svans 1.9
[4] Macedonia (4) 1.9
[4] Bulgaria 1.8
[4] Romanian 1.6
[4] Italy Bergamo 1.1
[4] Zambia Lusaka 1.1
[4] Belgium 1.0
[4] China North Han 1.0
[4] India Andhra Pradesh Golla 1.0
[4] Ireland Northern 1.0
[4] South Africian Natal Zulu 1.0

References[edit]

  1. ^ Hildebrand WH, Madrigal JA, Belich MP, et al. (1992). "Serologic cross-reactivities poorly reflect allelic relationships in the HLA-B12 and HLA-B21 groups. Dominant epitopes of the alpha 2 helix". J. Immunol. 149 (11): 3563–8. PMID 1385528. 
  2. ^ Marsh SG, Albert ED, Bodmer WF, et al. (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens. 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720. 
  3. ^ derived from IMGT/HLA
  4. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.  External link in |title= (help)