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Histatin 3
Symbols HTN3 ; HIS2; HTN2; HTN5
External IDs OMIM142702 HomoloGene133553 GeneCards: HTN3 Gene
RNA expression pattern
PBB GE HTN3 206786 at tn.png
More reference expression data
Species Human Mouse
Entrez 3347 n/a
Ensembl ENSG00000205649 n/a
UniProt P15516 n/a
RefSeq (mRNA) NM_000200 n/a
RefSeq (protein) NP_000191 n/a
Location (UCSC) Chr 4:
70.03 – 70.04 Mb
PubMed search [1] n/a

Histatin 3, also known as HTN3, is a protein which in humans is encoded by the HTN3 gene.[1][2]


The primary protein encoded by HTN3 is histatin 3. Histatins are a family of small, histidine-rich, salivary proteins, encoded by at least two loci (HTN3 and HTN1). Post-translational proteolytic processing results in many histatins: e.g., histatins 4-6 are derived from histatin 3 by proteolysis. Histatins 1 and 3 are primary products of HIS1(1) and HIS2(1) alleles, respectively. Histatins are believed to have important non-immunological, anti-microbial function in the oral cavity.[1] Histatin 1 and histatin 2 are major wound-closing factors in human saliva.[3]

allele gene protein
HIS1 HTN1 histatin 1
HIS2 HTN3 histatin 3 → histatins 4-6


  1. ^ a b "Entrez Gene: HTN3 histatin 3". 
  2. ^ Sabatini LM, Azen EA (April 1989). "Histatins, a family of salivary histidine-rich proteins, are encoded by at least two loci (HIS1 and HIS2)". Biochem. Biophys. Res. Commun. 160 (2): 495–502. doi:10.1016/0006-291X(89)92460-1. PMID 2719677. 
  3. ^ Oudhoff MJ, Bolscher JG, Nazmi K, Kalay H, van 't Hof W, Amerongen AV, Veerman EC (November 2008). "Histatins are the major wound-closure stimulating factors in human saliva as identified in a cell culture assay". FASEB J. 22 (11): 3805–12. doi:10.1096/fj.08-112003. PMID 18650243. 

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