Histatin 3

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AliasesHTN3, HIS2, HTN2, HTN5, histatin 3
External IDsHomoloGene: 133553 GeneCards: HTN3
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for HTN3
Genomic location for HTN3
Band4q13.3Start70,028,413 bp[1]
End70,036,538 bp[1]
RNA expression pattern
PBB GE HTN3 206786 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 4: 70.03 – 70.04 Mbn/a
PubMed search[2]n/a
View/Edit Human

Histatin 3, also known as HTN3, is a protein which in humans is encoded by the HTN3 gene.[3][4]


The primary protein encoded by HTN3 is histatin 3. Histatins are a family of small, histidine-rich, salivary proteins, encoded by at least two loci (HTN3 and HTN1). Post-translational proteolytic processing results in many histatins: e.g., histatins 4-6 are derived from histatin 3 by proteolysis. Histatins 1 and 3 are primary products of HIS1(1) and HIS2(1) alleles, respectively. Histatins are believed to have important non-immunological, anti-microbial function in the oral cavity.[3] Histatin 1 and histatin 2 are major wound-closing factors in human saliva.[5]

allele gene protein
HIS1 HTN1 histatin 1
HIS2 HTN3 histatin 3 → histatins 4-6


  1. ^ a b c ENSG00000282967 GRCh38: Ensembl release 89: ENSG00000205649, ENSG00000282967 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". 
  3. ^ a b "Entrez Gene: HTN3 histatin 3". 
  4. ^ Sabatini LM, Azen EA (April 1989). "Histatins, a family of salivary histidine-rich proteins, are encoded by at least two loci (HIS1 and HIS2)". Biochem. Biophys. Res. Commun. 160 (2): 495–502. doi:10.1016/0006-291X(89)92460-1. PMID 2719677. 
  5. ^ Oudhoff MJ, Bolscher JG, Nazmi K, Kalay H, van 't Hof W, Amerongen AV, Veerman EC (November 2008). "Histatins are the major wound-closure stimulating factors in human saliva as identified in a cell culture assay". FASEB J. 22 (11): 3805–12. doi:10.1096/fj.08-112003. PMID 18650243. 

Further reading[edit]