Melittin

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Melittin
PDB 2mlt EBI.jpg
Melittin
Identifiers
Symbol Melittin
Pfam PF01372
InterPro IPR002116
SCOP 2mlt
SUPERFAMILY 2mlt
TCDB 1.C.18
OPM superfamily 160
OPM protein 2mlt
Melittin[1]
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.157.496
MeSH Melitten
UNII
Properties
C131H229N39O31
Molar mass 2846.46266
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Melittin is the principal active component of apitoxin (bee venom). Melittin is a peptide consisting of 26 amino acids.

Research[edit]

In laboratory experiments, melittin inhibits protein kinase C, Ca2+/calmodulin-dependent protein kinase II, myosin light chain kinase, and Na+/K+-ATPase (synaptosomal membrane) and is a cell membrane lytic factor. Melittin is a small peptide with no disulfide bridge; the N-terminal part of the molecule is predominantly hydrophobic and the C-terminal part is hydrophilic and strongly basic.

Melittin is under basic research to describe its possible biological properties associated with negatively charged phospholipids, including potential anticancer effects revealed in laboratory research to involve mitochondria-mediated apoptosis.[2] Mellitin inhibits transport pumps such as the Na+-K+-ATPase and the H+-K+-ATPase. In vitro, melittin increases the permeability of cell membranes to ions,[2] particularly Na+ and indirectly Ca2+, because of the Na+-Ca2+-exchange. This effect results in morphological and functional changes, particularly in excitable tissues.[2]

References[edit]

External links[edit]