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Henry Brem

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Henry Brem, M.D.
EducationNew York University
Harvard University
Harvard Medical School
Peter Bent Brigham Hospital
Neurological Institute of New York
Columbia College of Physicians and Surgeons
Occupation(s)Harvey Cushing Professor, Director of the Department of Neurosurgery
Professor of Neurosurgery, Ophthalmology, Oncology and Biomedical Engineering
Neurosurgeon-in-Chief
Director, Hunterian Neurosurgical Research Center
Known forImage guidance computer system to deliver targeted chemotherapy to intraoperative brain tumors, viral mapping, vaccine development
Medical career
Fieldneurosurgeon, researcher, educator, inventor
InstitutionsJohns Hopkins

Henry Brem, M.D. is an American neurosurgeon, researcher, educator and inventor known for introducing an image guidance computer system to deliver targeted chemotherapy to intraoperative brain tumors.[1] As of 2023, he is the Harvey Cushing Professor, Director of the Department of Neurosurgery, Professor of Neurosurgery, Ophthalmology, Oncology and Biomedical Engineering Neurosurgeon-in-Chief, and Director, Hunterian Neurosurgical Research Center and Director at Johns Hopkins in Baltimore, Maryland.[2] Brem has written more than 490 peer-reviewed articles,[3] 50 books and book chapters and holds 11 patents.

Education and career

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Brem received his AB at New York University (1973) and Harvard University, Graduate School of Arts and Sciences Department of Biological Chemistry (1974), MD at Harvard Medical School, residencies at Peter Bent Brigham Hospital (Harvard) and the Neurological Institute of New York, Columbia College of Physicians and Surgeons.[4][5][6]

In 1998, he became a member of the National Academy of Medicine (NAM)[7]

Research

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Brem's fields of research include neurosurgery, brain tumors, drug delivery, angiogenesis and Immunology.[8] Brem's research on temozolomide, often linked to ribavirin, involves a combination of scientific disciplines and uncovers new connections. His work also connects epilepsy surgery with meningioma and implant chemotherapy. His carmustine research addresses wafer integration, biodistribution and cytotoxicity.[7]

He is credited along with Robert Langer for co-inventing the Gliadel® wafer, an implantable device that enables direct chemotherapy placement during brain tumor surgery.[9] This has led to other novel therapies, such as chemotherapy "cocktail" delivery systems by way of electrospun fiber membranes. This technology is being developed in conjunction with Andrew Steckl at the University of Cincinnati College of Engineering and Applied Science.[10]

Grants

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Brem has been the Principal- or Co-Investigator on 27 research studies focused on brain tumors and therapy delivery, such as controlled release polymers, brain-penetrating DNA nanoparticles, and enhancement of brain tumor immunotherapy.[11][12][13]

Patents

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  • Controlled Local Delivery of Chemotherapeutic Agents for Treating Solid Tumors[14] Henry Brem, Robert S. Langer, Abraham J. Domb
  • Cytokine Enhanced Immunotherapy for Brain Tumors[15] Henry Brem, Drew M. Pardoll, Reid C. Thompson, Elizabeth M. Jaffee, Kam W. Leong, Matthew G. Ewend
  • Antibiotic Composition for Inhibition of Angiogenesis[16]  Henry Brem, Rafael J. Tamargo, Robert A. Bok
  • Vitamin D3 Analog Loaded Polymer Formulations for Cancer and Neurogenerative Disorders[17]  Martin Burke, Maria-Christina White, Jae Kyoo Lee, Mark C. Watts, Betty M. Tyler, Gary H. Posner, Henry Brem.[18]
  • Intracellular Delivery of Anionic Anti-cancer Drugs with Cationic Polymers D. Berry, G. Anderson, R Langer, B Tyler, H. Brem.[citation needed]
  • Combination of Local Temozolomide with Local BCNU[19] V. Renard Recinos, B. Tyler, S. Brem Sunshine, H. Brem.
  • Use of Adjuvant Focused Radiation Including Stereotactic Radiosurgery for Augmenting Immune Based Therapies Against Neoplasms[20]
  • Intraoperatively Placed Markers for Post-surgical Imaging M. Lim, H. Brem, B.Tyler, J. Liauw, S. Lo
  • Local Delivery Forms of Acriflavine for Treating Tumors[21] Brem H, Mangraviti A, Olivi A, Tyler B, Raghavan T.
  • Flexible Control and Guidance of Minimally Invasive Focused Ultrasound[22]  Manbachi A, Siewerdsen J, Ellens N, Zhang X, Belzberg M, Cohen A, Brem H.
  • Combination of Immunotherapy with Local Chemotherapy for the Treatment of Malignancies[22]  Dimitrios M, Tyler B, Pardoll D, Brem H, Lim M

Publications

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Books and chapters

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As of 2023, Brem has written 58 book chapters and monographs. Books include: Guest Editor, Special Edition: Implant Approach to Chemotherapy, (JNO) 1995, Section Editor, Youmans Textbook of Neurological Surgery-5th Edition, 2004 ISBN 072163933X, and Section Editor, Youmans Textbook of Neurological Surgery-6th Edition, 2011.

Peer-reviewed articles

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According to Google Scholar, Brem has, as of 2024, been cited 42,023 times, has an h-index of 102 and an i10-index of 350.[8] His 10 most cited works include:

  • Detection of circulating tumor DNA in early-and late-stage human malignancies, doi: 10.1126/scitranslmed.3007094. PMID 24553385 4,173 citations[23]
  • Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas, doi: 10.1016/s0140-6736(95)90755-6  PMID 7723496  1,646 citations[24]
  • Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells, doi: 10.1038/nature05349. PMID 17151667 1,403 citations[25]
  • Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas, doi: 10.1016/j.ijrobp.2012.12.025 PMID 23462419 919 citations[26]
  • Survival following surgery and prognostic factors for recently diagnosed malignant glioma: data from the Glioma Outcomes Project, doi: 10.3171/jns.2003.99.3.0467. PMID 12959431 855 citations[27]
  • Independent association of extent of resection with survival in patients with malignant brain astrocytoma, doi: 10.3171/2008.4.17536 PMID 18847342 828 citations[28]
  • Polylactic acid (PLA) controlled delivery carriers for biomedical applications,  doi: 10.1016/j.addr.2016.06.018 PMID 27426411 734 citations[29]
  • Interstitial chemotherapy with drug polymer implants for the treatment of recurrent gliomas, doi: 10.3171/jns.1991.74.3.0441. PMID 1993909 645 citations[30]
  • Multi-pulse drug delivery from a resorbable polymeric microchip device, doi: 10.1038/nmat998 PMID 14619935  626 citations[31]
  • Extent of surgical resection is independently associated with survival in patients with hemispheric infiltrating low-grade gliomas, doi: 10.1227/01.NEU.0000325729.41085.73 PMID 18981880  595 citations[32]

References

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  1. ^ "Henry Brem, Neurosurgeon-in-Chief, Chairman, Director, Professor - eMedEvents". www.emedevents.com. Retrieved 2023-06-12.
  2. ^ "Henry Brem, M.D. | Candel Therapeutics". 2021-04-13. Retrieved 2023-06-14.
  3. ^ "Henry Brem's Research". ResearchGate. Retrieved June 14, 2023.
  4. ^ "Henry Brem, M.D. | Catalio Capital Management". www.cataliocapital.com. Retrieved 2023-06-12.
  5. ^ "Dr. Henry Brem". U.S. News and World Report. Retrieved June 12, 2023.
  6. ^ "Dr. Henry Brem - Neurological Surgery - Baltimore, MD". Castle Connolly. Retrieved 2023-06-14.
  7. ^ a b "Henry Brem". Research.com. Retrieved June 14, 2023.
  8. ^ a b "Henry Brem". scholar.google.com. Retrieved 2023-06-12.
  9. ^ Media, BioBuzz (2022-11-16). "CraniUS Appoints World Leading Johns Hopkins Neurosurgeon Dr. Henry Brem to Join Board of Directors · BioBuzz". BioBuzz. Retrieved 2023-06-14.
  10. ^ Miller, Michael; Cincinnati, University of. "New treatment for brain tumors uses electrospun fiber". phys.org. Retrieved 2023-06-14.
  11. ^ Brem, Henry. "Controlled Release Polymers for Brain Tumors (U19 CA 528". Grantome.
  12. ^ Hanes, Justin; Suk, Jung. "Targeted Delivery of Brain Penetrating DNA Nanoparticles to Brain Tumors". Grantome.
  13. ^ Lesniak, M. S.; Langer, R.; Brem, H. "Drug delivery to tumors of the central nervous system". Current Neurology and Neuroscience Reports. 1 (3): 210–216. doi:10.1007/s11910-001-0020-z. ISSN 1528-4042.
  14. ^ US5626862A, Brem, Henry; Langer, Robert S. & Domb, Abraham J., "Controlled local delivery of chemotherapeutic agents for treating solid tumors", issued 1997-05-06 
  15. ^ EP0930892A1, Brem, Henry; Pardoll, Drew M. & Thompson, Reid C. et al., "Cytokine enhanced immunotherapy for brain tumors", issued 1999-07-28 
  16. ^ US6482810B1, Brem, Henry; Tamargo, Rafael J. & Bok, Robert A., "Antibiotic composition for inhibition of angiogenesis", issued 2002-11-19 
  17. ^ US20080260834A1, Burke, Martin; White, Maria-Christina & Watts, Mark C. et al., "Vitamin d3 analog loaded polymer formulations for cancer and neurodegenerative disorders", issued 2008-10-23 
  18. ^ US20080260834A1, Burke, Martin; White, Maria-Christina & Watts, Mark C. et al., "Vitamin d3 analog loaded polymer formulations for cancer and neurodegenerative disorders", issued 2008-10-23 
  19. ^ US8895597B2, Recinos, Violette Renard; Tyler, Betty & Sunshine, Sarah Brem et al., "Combination of local temozolomide with local BCNU", issued 2014-11-25 
  20. ^ WO2012177624A2, Zeng, Jing; Drake, Charles George & Pardoll, Drew M. et al., "Focused radiation for augmenting immune-based therapies against neoplasms", issued 2012-12-27 
  21. ^ US20180036301A1, Brem, Henry; Mangraviti, Antonella & Olivi, Alessandro et al., "Local delivery forms of acriflavine for treating tumors", issued 2018-02-08 
  22. ^ a b US20200001121A1, Manbachi, Amir; Siewerdsen, Jeffrey & Ellens, Nicholas et al., "Flexible control and guidance of minimally invasive focused ultrasound", issued 2020-01-02 
  23. ^ "Detection of circulating tumor DNA in early-and late-stage human malignancies". scholar.google.com. Retrieved 2023-06-12.
  24. ^ "Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas". scholar.google.com. Retrieved 2023-06-12.
  25. ^ "Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells". scholar.google.com. Retrieved 2023-06-12.
  26. ^ "Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas". scholar.google.com. Retrieved 2023-06-12.
  27. ^ "Survival following surgery and prognostic factors for recently diagnosed malignant glioma: data from the Glioma Outcomes Project". scholar.google.com. Retrieved 2023-06-12.
  28. ^ "Independent association of extent of resection with survival in patients with malignant brain astrocytoma". scholar.google.com. Retrieved 2023-06-12.
  29. ^ "Polylactic acid (PLA) controlled delivery carriers for biomedical applications". scholar.google.com. Retrieved 2023-06-12.
  30. ^ "Interstitial chemotherapy with drug polymer implants for the treatment of recurrent gliomas". scholar.google.com. Retrieved 2023-06-12.
  31. ^ "Multi-pulse drug delivery from a resorbable polymeric microchip device". scholar.google.com. Retrieved 2023-06-12.
  32. ^ "Extent of surgical resection is independently associated with survival in patients with hemispheric infiltrating low-grade gliomas". scholar.google.com. Retrieved 2023-06-12.
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