Robert S. Langer
Robert Samuel Langer, Jr. FREng (born August 29, 1948) is an American chemical engineer, scientist, entrepreneur, inventor and one of the twelve Institute Professors at the Massachusetts Institute of Technology.
He was formerly the Germeshausen Professor of Chemical and Biomedical Engineering and maintains activity in the Department of Chemical Engineering and the Department of Biological Engineering at MIT. He is also a faculty member of the Harvard–MIT Program in Health Sciences and Technology and the Koch Institute for Integrative Cancer Research.
Langer holds over 1,400 granted or pending patents. He is one of the world's most highly cited researchers and his h-index is now 292 with currently over 350,000 citations. He is a widely recognized and cited researcher in biotechnology, especially in the fields of drug delivery systems and tissue engineering.
He is the most cited engineer in history and 4th most cited individual in any field, having authored over 1,500 scientific papers, and is also a prolific entrepreneur, having participated in the founding of over 40 biotechnology companies including Moderna.
Langer's research laboratory at MIT is the largest biomedical engineering lab in the world; maintaining over $10 million in annual grants and over 100 researchers. He has been awarded numerous leading prizes in recognition of his work.
Background and personal life
Langer was born August 29, 1948 in Albany, New York, US. He is an alumnus of The Milne School and received his bachelor's degree from Cornell University in chemical engineering. He earned his Sc.D. in chemical engineering from Massachusetts Institute of Technology in 1974. His dissertation was entitled "Enzymatic regeneration of ATP" and completed under the direction of Clark K. Colton. From 1974–1977 he worked as a postdoctoral fellow for cancer researcher Judah Folkman at the Children's Hospital Boston and at Harvard Medical School. Langer credits Folkman as a fantastic role model. Langer and his wife, Laura, a fellow MIT graduate, have three children.
Contributions to medicine and biotechnology
Langer is widely regarded for his contributions to medicine and biotechnology. He is considered a pioneer of many new technologies, including controlled release systems and transdermal delivery systems, which allow the administration of drugs or extraction of analytes from the body through the skin without needles or other invasive methods.
Langer worked with Judah Folkman at Boston Children's Hospital to isolate the first angiogenesis inhibitor, a macromolecule to block the spread of blood vessels in tumors. Macromolecules tend to be broken down by digestion and blocked by body tissues if they are injected or inhaled, so finding a delivery system for them is difficult. Langer's idea was to encapsulate the angiogenesis inhibitor in a noninflammatory synthetic polymer system that could be implanted in the tumor and control the release of the inhibitor. He eventually invented polymer systems that would work. This discovery is considered to lay the foundation for much of today's drug delivery technology.
Langer also worked with Henry Brem of the Johns Hopkins University Medical School on a drug-delivery system for the treatment of brain cancer, to deliver chemotherapy directly to a tumor site. The wafer implants that he and his teams have designed have become increasingly more sophisticated, and can now deliver multiple drugs, and respond to stimuli. In 2019, he and his team developed and patented a technique whereby microneedle tattoo patches could be used to label people with invisible ink to store medical information subcutaneously. This was presented as a boon to "developing nations" where lack of infrastructure means an absence of medical records. The technology uses a "quantum dot dye that is delivered, along with a vaccine, by a microneedle patch."
Langer is regarded as the founder of tissue engineering in regenerative medicine. He and the researchers in his lab have made advances in tissue engineering, such as the creation of engineered blood vessels and vascularized engineered muscle tissue. Bioengineered synthetic polymers provide a scaffolding on which new skin, muscle, bone, and entire organs can be grown. With such a substrate in place, victims of serious accidents or birth defects could more easily grow missing tissue. Such polymers can be biocompatible and biodegradable.
Langer is involved in several projects related to diabetes. Alongside Daniel G. Anderson, he has contributed bioengineering work to a project involving teams from MIT, Harvard University and other institutions, to produce an implantable device to treat type 1 diabetes by shielding insulin-producing beta cells from immune system attacks. He is also part of a team at MIT that have developed a drug capsule that could be used to deliver oral doses of insulin to people with type 1 diabetes.
Awards and honors
Langer is the youngest person in history (at 43) to be elected to all three American science academies: the National Academy of Sciences, the National Academy of Engineering and the National Academy of Medicine. He was also elected as a charter member of National Academy of Inventors. He was elected as an International Fellow of the Royal Academy of Engineering in 2010.
Langer has received more than 220 major awards. He is one of three living individuals to have received both the U.S. National Medal of Science and the National Medal of Technology and Innovation.
- 2002: Dickson Prize in Science
- 2002: Charles Stark Draper Prize (considered the equivalent of the Nobel Prize for engineers).
- 2003: Golden Plate Award of the American Academy of Achievement
- 2008: Max Planck Research Award 2008
- 2008: Prince of Asturias Award for Scientific Research
- 2008: Awarded Finland's Millennium Technology Prize for developing innovative biomaterials for controlled drug release.
- 2010: Elected an International Fellow of the Royal Academy of Engineering.
- 2011: The Economist's Innovation award in the category of bioscience for his proven successes in drug-delivery and tissue engineering.
- 2011: Warren Alpert Foundation Prize
- 2012: Perkin Medal, recognized as the highest honor given for outstanding work in applied chemistry in the United States.
- 2012: Wilhelm Exner Medal.
- 2012: Priestley Medal, the highest honor conferred by the American Chemical Society (ACS), for distinguished service in the field of chemistry.
- 2013: United States National Medal of Technology and Innovation from President Obama. He had previously received the United States National Medal of Science, in 2006, from President George W. Bush.
- 2013: Wolf Prize in Chemistry for conceiving and implementing advances in polymer chemistry that provide both controlled drug-release systems and new biomaterials.
- 2013: IEEE Medal for Innovations in Healthcare Technology
- 2014: The Biotechnology Industry Organization (BIO) and the Chemical Heritage Foundation selected Robert Langer as the winner of the 2014 Biotechnology Heritage Award for significant contribution to the growth of biotechnology.
- 2014: Awarded the $3 million Breakthrough Prize in Life Sciences for his work.
- 2014: Kyoto Prize
- 2015: Queen Elizabeth Prize for Engineering
- 2015: Named Cornell University's 2015 Entrepreneur of the Year.
- 2015: Scheele Award
- 2015: Kazemi Prize (Royan Institute)
- 2015: Hoover Medal
- 2016: European Inventor Award
- 2016: Benjamin Franklin Medal in Life Science
- 2017: Kabiller Prize in Nanoscience and Nanomedicine
- 2017: Named 1# Translational Researcher in the World by Nature Biotechnology.
- 2018: Named 1# Translational Researcher in the World by Nature Biotechnology.
- 2018: Leadership Award for Historic Scientific Advancement, American Chemical Society
- 2018: Inducted into Advanced Materials Hall of Fame
- 2019: Hope Funds for Cancer Award of Excellence in Basic Sciences
- 2019: National Library of Medicine (Friends) Distinguished Medical Science Award
- 2019: Dreyfus Prize in the Chemical Sciences
- 2020: Maurice Marie-Janot Award
- 2020: Medalha da Ciência, Highest Distinction for Scientists, Government of Portugal (Portugal's Highest Honor)
He has received numerous other awards, including the Gairdner Foundation International Award (1996), the Lemelson-MIT Prize for invention and innovation (1998), the Othmer Gold Medal (2002), the 10th Annual Heinz Award in the category of Technology, the Economy and Employment (2003), the Harvey Prize in Science & Technology and Human Health (2003), the Dan David Prize (2005) and the Albany Medical Center Prize in Medicine and Biomedical Research (2005). In 2013 he was awarded the IRI Medal alongside long-time friend George M. Whitesides for outstanding accomplishments in technological innovation that have contributed broadly to the development of industry and the benefit of society. He also received the Rusnano prize that year. He has also given 137 named lectures and commencement speeches.
Langer has honorary degrees from 36 universities from around the world including Harvard, Yale, and Columbia University.
Founder of various biotech companies
Robert Langer has been involved in the founding of many companies, more than twenty in partnership with the venture capital firm Polaris Partners. Success of these companies and Langer's contribution has been detailed by Harvard Business Review:
- AIR (acquired by Alkermes and subsequently acquired by Acorda)
- Arsenal Medical
- Arsia (acquired by Eagle Pharmaceuticals)
- BIND Therapeutics (acquired by Pfizer)
- Tarveda Therapeutics (formerly Blend Therapeutics)
- Sontra Medical (acquired by Echo Therapeutics)
- Enzytech (acquired by Alkermes)
- Tissium (formerly Gecko Biomedical)
- InVivo Therapeutics
- Landsdowne Labs
- Living Proof (acquired by Unilever)
- Lyra Therapeutics
- Lyndra Therapeutics
- Microchips Biotech (acquired by Dare)
- Momenta (acquired by Johnson and Johnson)
- Olivo Labs (acquired by Shisheido)
- Pervasis (acquired by Shire Pharmaceuticals)
- Selecta Biosciences
- Semprus Biosciences (acquired by Teleflex)
- Seventh Sense
- SQZ Biotech
- Taris (acquired by Johnson and Johnson)
- Transform (acquired by Johnson and Johnson)
- Frequency Therapeutics
- Sigilon Therapeutics
- Seer Bio
Langer is a member of the Advisory Board of Patient Innovation, a nonprofit, international, multilingual, free venue for patients and caregivers of any disease to share their innovations. He is also a member of the Xconomists, an ad hoc team of editorial advisors for the tech news and media company, Xconomy.
Exhibits at Boston's Logan Airport
Langer is featured in two different exhibits at Boston's Logan Airport. At terminal C (near Gate 8) in the exhibit '4 centuries of Massachusetts Innovation', Langer and Judah Folkman are listed for 'Cancer breakthrough-1st cancer blood vessel inhibitor'. In terminal E, Massachusetts innovators-Transforming the world, Langer is featured as "Revolutionary Biomedical Technology through Development of Controlled Drug Delivery Systems" (near Gate 12).
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A chemical engineer by training, Dr. Langer has helped start 25 companies and has 811 patents, issued or pending, to his name. ...
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- Mitragotri, S; Blankschtein, D; Langer, R (1995). "Ultrasound-mediated transdermal protein delivery". Science. 269 (5225): 850–3. Bibcode:1995Sci...269..850M. doi:10.1126/science.7638603. PMID 7638603. S2CID 26069484.
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- Langer, Robert; Folkman, Judah (October 1976). "Polymers for the sustained release of proteins and other macromolecules". Nature. 263 (5580): 797–800. Bibcode:1976Natur.263..797L. doi:10.1038/263797a0. PMID 995197. S2CID 4210402.
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- Levenberg, S; Rouwkema, J; MacDonald, M; Garfein, ES; Kohane, DS; Darland, DC; Marini, R; Van Blitterswijk, CA; et al. (2005). "Engineering vascularized skeletal muscle tissue". Nature Biotechnology. 23 (7): 879–84. doi:10.1038/nbt1109. PMID 15965465. S2CID 28136064.
- Vacanti, Joseph P; Langer, Robert (July 1999). "Tissue engineering: the design and fabrication of living replacement devices for surgical reconstruction and transplantation". The Lancet. 354: S32–S34. doi:10.1016/s0140-6736(99)90247-7. PMID 10437854. S2CID 33614316. Retrieved 6 February 2014.
- Freed, Lisa E.; Vunjak-Novakovic, Gordana; Biron, Robert J.; Eagles, Dana B.; Lesnoy, Daniel C.; Barlow, Sandra K.; Langer, Robert (July 1994). "Biodegradable Polymer Scaffolds for Tissue Engineering". Bio/Technology. 12 (7): 689–693. doi:10.1038/nbt0794-689. PMID 7764913. S2CID 22968473.
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- Anderson, Daniel G.; Langer, Robert; Melton, Douglas A.; Weir, Gordon C.; Greiner, Dale L.; Oberholzer, Jose; Hollister-Lock, Jennifer; Bochenek, Matthew A.; McGarrigle, James J. (2016-01-25). "Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice". Nature Medicine. 22 (3): 306–311. doi:10.1038/nm.4030. ISSN 1546-170X. PMC 4825868. PMID 26808346.
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