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Heptaprenyl diphosphate synthase

From Wikipedia, the free encyclopedia
heptaprenyl diphosphate synthase
Identifiers
EC no.2.5.1.30
CAS no.74506-59-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a heptaprenyl diphosphate synthase (EC 2.5.1.30) is an enzyme that catalyzes the chemical reaction

(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate 4 diphosphate + all-trans-heptaprenyl diphosphate

Thus, the two substrates of this enzyme are (2E,6E)-farnesyl diphosphate and isopentenyl diphosphate, whereas its two products are diphosphate and all-trans-heptaprenyl diphosphate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 4 isopentenyl units). Other names in common use include all-trans-heptaprenyl-diphosphate synthase, heptaprenyl pyrophosphate synthase, and heptaprenyl pyrophosphate synthetase. This enzyme participates in biosynthesis of steroids.

Structural studies

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As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes 2E8T, 2E8U, 2E8V, 2E8W, 2E8X, 2E90, 2E91, 2E92, 2E93, 2E94, and 2E95.

References

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  • Takahashi I, Ogura K, Seto S (1980). "Heptaprenyl pyrophosphate synthetase from Bacillus subtilis". J. Biol. Chem. 255 (10): 4539–43. doi:10.1016/S0021-9258(19)85526-6. PMID 6768722.