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Histone-arginine N-methyltransferase

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Histone-arginine N-methyltransferase
Identifiers
EC no.2.1.1.125
CAS no.445295-80-7
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IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
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Histone-arginine N-methyltransferase (EC 2.1.1.125, histone protein methylase I, nuclear protein (histone) N-methyltransferase, protein methylase I, S-adenosyl-L-methionine:histone-arginine omega-N-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:histone-arginine Nomega-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + histone-arginine S-adenosyl-L-homocysteine + histone-Nomega-methyl-arginine

The enzyme forms the Nomega-monomethyl- and Nomega,Nomega'-dimethyl.

References

  1. ^ Rajpurohit, R., Lee, S.O., Paik, W.K., Kim, S. (1994). "Enzymatic methylation of recombinant heterogeneous nuclear RNP protein A1. Dual substrate specificity for S-adenosylmethionine: histone-arginine-N-methyltransferase". J. Biol. Chem. 269 (2): 1075–1082. PMID 8288564.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. ^ Rawal, N., Rajpurohit, R., Paik, W.K., Kim, S. (1994). "Purification and characterization of S-adenosylmethionine-protein-arginine-N-methyltransferase from rat liver". Biochem. J. 300 (Pt 2): 483–489. PMC 1138188. PMID 8002954.{{cite journal}}: CS1 maint: multiple names: authors list (link)