|Location||401 Main St.
|Architect||Hugh L. Cooper|
|NRHP Reference #||87000022|
|Added to NRHP||February 5, 1987|
The Hotel Iowa is a historic building in downtown Keokuk, Iowa, United States. It was built from 1912–1913 and it was listed on the National Register of Historic Places in 1975. The structure, which was designed by architect Guy C. Mariner  in the Chicago Commercial style, was built to house the workers who built Lock and Dam No. 19 on the Mississippi River. The eight-story structure became a commercial building known as the Pierce Building.