Hymecromone

Hymecromone
Clinical data
Other names	4-Methylumbelliferone
AHFS/Drugs.com	International Drug Names
ATC code	A05AX02 (WHO) ;
Identifiers
	IUPAC name 7-Hydroxy-4-methylchromen-2-one;
CAS Number	90-33-5 ;
PubChem CID	5280567;
DrugBank	DB07118 ;
ChemSpider	4444190 ;
UNII	3T5NG4Q468;
KEGG	D00170 ;
ChEBI	CHEBI:17224 ;
ChEMBL	ChEMBL12208 ;
CompTox Dashboard (EPA)	DTXSID8025670 ;
ECHA InfoCard	100.001.806
Chemical and physical data
Formula	C10H8O3
Molar mass	176.171 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=CC(=O)OC2=C1C=CC(=C2)O;
	InChI InChI=1S/C10H8O3/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9/h2-5,11H,1H3 ; Key:HSHNITRMYYLLCV-UHFFFAOYSA-N ;
	(verify)

Hymecromone (4-methylumbelliferone) is a drug used in bile therapy. It is used as choleretic and antispasmodic drugs and as a standard for the fluorometric determination of enzyme activity.^[1]

Hymecromone is a crystalline solid with a melting point of 194–195 °C. It is soluble in methanol and glacial acetic acid.

References

^ Yang Y, Hamaguchi K (April 1980). "Hydrolysis of 4-methylumbelliferyl N-acetyl-chitotrioside catalyzed by hen and turkey lysozymes. pH dependence of the kinetics constants". Journal of Biochemistry. 87 (4): 1003–14. doi:10.1093/oxfordjournals.jbchem.a132833. PMID 7390976.

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[pmid7390976-1] Yang Y, Hamaguchi K (April 1980). "Hydrolysis of 4-methylumbelliferyl N-acetyl-chitotrioside catalyzed by hen and turkey lysozymes. pH dependence of the kinetics constants". Journal of Biochemistry. 87 (4): 1003–14. doi:10.1093/oxfordjournals.jbchem.a132833. PMID 7390976.

[1]

v t e Bile and liver therapy (A05)
Bile therapy	bile acid Chenodeoxycholic acid Cholic acid Obeticholic acid Ursodeoxycholic acid Ursodoxicoltaurine Cyclobutyrol Elafibranor Hymecromone Maralixibat chloride Menbutone Nicotinyl methylamide Odevixibat Piprozolin
Liver therapy	Arginine glutamate Citiolone Epomediol Glycyrrhizin Metadoxine Methionine Ornithine oxoglutarate Phospholipids Silymarin Tidiacic arginine

See also

References