Phenprocoumon

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Phenprocoumon
Phenprocoumon.svg
Clinical data
Trade names Marcoumar, Marcumar, Falithrom
AHFS/Drugs.com International Drug Names
MedlinePlus a699003
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Protein binding 99%
Metabolism hepatic to inactive metabolites
Biological half-life 5 to 6 days
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard 100.006.464
Chemical and physical data
Formula C18H16O3
Molar mass 280.318 g/mol
3D model (Jmol)
  (verify)

Phenprocoumon (marketed under the brand names Marcoumar, Marcumar and Falithrom) is a long-acting oral anticoagulant drug, a derivative of coumarin. It is a vitamin K antagonist that inhibits coagulation by blocking synthesis of coagulation factors II, VII, IX and X. It is used for the prophylaxis and treatment of thromboembolic disorders (thrombosis/pulmonary embolism). It is the standard coumarin used in Germany.

Phenprocoumon is a 4-hydroxycoumarin and inhibits vitamin K epoxide reductase.[1]

References[edit]

  1. ^ Phenprocoumon at PharmGKB

External links[edit]