Phenprocoumon

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Phenprocoumon
Phenprocoumon.svg
Clinical data
Trade namesMarcoumar, Marcumar, Falithrom
AHFS/Drugs.comInternational Drug Names
MedlinePlusa699003
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Protein binding99%
Metabolismhepatic to inactive metabolites
Elimination half-life5 to 6 days
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.006.464 Edit this at Wikidata
Chemical and physical data
FormulaC18H16O3
Molar mass280.318 g/mol g·mol−1
3D model (JSmol)
  (verify)

Phenprocoumon (marketed under the brand names Marcoumar, Marcumar and Falithrom) is a long-acting oral anticoagulant drug, a derivative of coumarin. It is a vitamin K antagonist that inhibits coagulation by blocking synthesis of coagulation factors II, VII, IX and X. It is used for the prophylaxis and treatment of thromboembolic disorders (thrombosis/pulmonary embolism). It is the standard coumarin used in Germany.

Phenprocoumon is a 4-hydroxycoumarin and inhibits vitamin K epoxide reductase.[1]

References[edit]

  1. ^ Phenprocoumon at PharmGKB

External links[edit]