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AliasesITIH2, H2P, SHAP, inter-alpha-trypsin inhibitor heavy chain 2
External IDsOMIM: 146640 MGI: 96619 HomoloGene: 1668 GeneCards: ITIH2
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for ITIH2
Genomic location for ITIH2
Band10p14Start7,703,316 bp[1]
End7,749,520 bp[1]
RNA expression pattern
PBB GE ITIH2 204987 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 10: 7.7 – 7.75 MbChr 2: 10.09 – 10.13 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Inter-alpha-trypsin inhibitor heavy chain H2 is a protein that in humans is encoded by the ITIH2 gene.[5][6][7]

It is known to contain a Gla domain, and thus be dependent for production on post translational modification requiring vitamin K. Its function is also presumably dependent on calcium ions.

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000151655 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037254 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Salier JP, Simon D, Rouet P, Raguenez G, Muscatelli F, Gebhard W, Guenet JL, Mattei MG (Dec 1992). "Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily". Genomics. 14 (1): 83–8. doi:10.1016/S0888-7543(05)80287-3. PMID 1385302.
  6. ^ Jean L, Risler JL, Nagase T, Coulouarn C, Nomura N, Salier JP (May 1999). "The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?". FEBS Lett. 446 (1): 6–8. doi:10.1016/S0014-5793(99)00173-8. PMID 10100603. S2CID 84807160.
  7. ^ "Entrez Gene: ITIH2 inter-alpha (globulin) inhibitor H2".

Further reading[edit]