ITM2B

ITM2B
Identifiers
Aliases	ITM2B, ABRI, BRI, BRI2, BRICD2B, E25B, E3-16, FBD, imBRI2, RDGCA, integral membrane protein 2B
External IDs	OMIM: 603904; MGI: 1309517; HomoloGene: 7388; GeneCards: ITM2B; OMA:ITM2B - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	48,270,357 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	73,622,729 bp
RNA expression pattern
	Top expressed in
	glomerulus; ; metanephric glomerulus; ; corpus epididymis; ; germinal epithelium; ; kidney tubule; ; visceral pleura; ; jejunal mucosa; ; renal medulla; ; parietal pleura; ; caput epididymis;
	Top expressed in
	stroma of bone marrow; ; vestibular sensory epithelium; ; skin of external ear; ; molar; ; lobe of prostate; ; transitional epithelium of urinary bladder; ; right lung; ; calvaria; ; right lung lobe; ; efferent ductule;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	amyloid-beta binding; protein binding; ATP binding;
Cellular component	integral component of organelle membrane; extracellular region; integral component of membrane; Golgi-associated vesicle membrane; Golgi membrane; endosome; plasma membrane; Golgi apparatus; endosome membrane; extracellular exosome; membrane; intracellular membrane-bounded organelle; extracellular space;
Biological process	nervous system development; negative regulation of amyloid precursor protein biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	9445
	16432
	ENSG00000136156
	ENSMUSG00000022108
	Q9Y287
	O89051
	NM_021999
	NM_008410
	NP_068839
	NP_032436
	Wikidata
View/Edit Human	View/Edit Mouse

Template:PBB Summary

Integral membrane protein 2B (ITM2B or BRI2) is a protein that in humans is encoded by the ITM2B gene.^[5]^[6]

ITM2B or BRI2 is a gene located on chromosome 13. The gene is connected to familial Danish dementia and familial British dementia causing amyloid and pre-filbrillar effects similar to those seen in Alzheimer's.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136156 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022108 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pittois K, Deleersnijder W, Merregaert J (Nov 1998). "cDNA sequence analysis, chromosomal assignment and expression pattern of the gene coding for integral membrane protein 2B". Gene. 217 (1–2): 141–9. doi:10.1016/S0378-1119(98)00354-0. PMID 9795190.
^ "Entrez Gene: ITM2B integral membrane protein 2B".

References

Further reading