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Aliases IWS1, SUPT6H interacting protein
External IDs MGI: 1920723 HomoloGene: 134421 GeneCards: IWS1
RNA expression pattern
PBB GE IWS1 gnf1h08910 s at fs.png

PBB GE IWS1 gnf1h08911 x at fs.png

PBB GE IWS1 gnf1h08909 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 2: 127.44 – 127.53 Mb Chr 18: 32.07 – 32.1 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Protein IWS1 homolog also known as interacts with Spt6 (IWS1) is a protein that in humans is encoded by the IWS1 gene.[3]

IWS1 an transcription elongation factor. It was first identified during a search for RNA polymerase II-associated elongation factors in yeast; it directly interacts with RNA polymerase II (RNAPII) and is phosphorylated at casein kinase II (CKII) sites.[4] The human homolog, which physically interacts with protein arginine methyltransferase 5 (PRMT5), is essential for cell survival.[5] It also recruits a SET2 histone methyltransferase (Huntingtin-interacting protein HYPB, also known as SETD2) to RNAPII during transcription elongation and is required for H3K36 trimethylation.[6]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ "Entrez Gene: IWS1 IWS1 homolog (S. cerevisiae)". 
  4. ^ Krogan NJ, Kim M, Ahn SH, Zhong G, Kobor MS, Cagney G, Emili A, Shilatifard A, Buratowski S, Greenblatt JF (Oct 2002). "RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach". Molecular and Cellular Biology. 22 (20): 6979–92. doi:10.1128/MCB.22.20.6979-6992.2002. PMC 139818Freely accessible. PMID 12242279. 
  5. ^ Liu Z, Zhou Z, Chen G, Bao S (Feb 2007). "A putative transcriptional elongation factor hIws1 is essential for mammalian cell proliferation". Biochemical and Biophysical Research Communications. 353 (1): 47–53. doi:10.1016/j.bbrc.2006.11.133. PMID 17184735. 
  6. ^ Yoh SM, Lucas JS, Jones KA (Dec 2008). "The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation". Genes & Development. 22 (24): 3422–34. doi:10.1101/gad.1720008. PMC 2607075Freely accessible. PMID 19141475. 

Further reading[edit]