Estradiol cypionate/medroxyprogesterone acetate

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Estradiol cypionate/medroxyprogesterone acetate
Combination of
Estradiol cypionate Estrogen
Medroxyprogesterone acetate Progestogen
Clinical data
Trade names Lunelle, Cyclofem, others[1]
AHFS/ Micromedex Detailed Consumer Information
  • US: X (Contraindicated)
Routes of
ATC code
Legal status
Legal status

Estradiol cypionate/medroxyprogesterone acetate, sold under the brand name Lunelle among others, is a form of combined injectable birth control. It contains estradiol cypionate an estrogen and medroxyprogesterone acetate a progestin.[2] It is recommended for short-term use and is given once a month by injection into a muscle.[3]

Common side effects include irregular menstrual periods which typically improves with time. Other side effects include blood clots, headache, hair loss, depression, nausea, and breast pain.[3][4] Use during pregnancy is not recommended.[2] Use during breastfeeding is likely safe.[5] It works mainly by preventing ovulation.[2]

Estradiol cypionate/medroxyprogesterone acetate came into medical use in 1993 with approval in the United States in 2000.[6][2] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[7] It is used in Mexico, Thailand and Indonesia among other countries.[6] It is no longer commercially available in the United States.[2]


  1. ^ Humans, IARC Working Group on the Evaluation of Carcinogenic Risks to; Organization, World Health; Cancer, International Agency for Research on (2007). Combined Estrogen-progestogen Contraceptives and Combined Estrogen-progestogen Menopausal Therapy. World Health Organization. p. 431. ISBN 9789283212911. 
  2. ^ a b c d e "Estradiol and medroxyprogesterone Intramuscular Advanced Patient Information -". Retrieved 1 January 2017. 
  3. ^ a b WHO Model Formulary 2008 (PDF). World Health Organization. 2009. pp. 368–370. ISBN 9789241547659. Retrieved 8 December 2016. 
  4. ^ "Estradiol/medroxyprogesterone Side Effects in Detail -". Retrieved 1 January 2017. 
  5. ^ "Estradiol / medroxyprogesterone (Lunelle) Use During Pregnancy". Retrieved 1 January 2017. 
  6. ^ a b Senanayake, Pramilla; Potts, Malcolm (2008). Atlas of Contraception, Second Edition (2 ed.). CRC Press. p. 51. ISBN 9780203347324. 
  7. ^ "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Retrieved 8 December 2016.