Estradiol cypionate/medroxyprogesterone acetate
|Trade names||Lunelle, Cyclofem, others|
|AHFS/Drugs.com||Micromedex Detailed Consumer Information|
Estradiol cypionate/medroxyprogesterone acetate, sold under the brand name Lunelle among others, is a form of combined injectable birth control. It contains estradiol cypionate an estrogen and medroxyprogesterone acetate a progestin. It is recommended for short-term use and is given once a month by injection into a muscle.
Common side effects include irregular menstrual periods which typically improves with time. Other side effects include blood clots, headache, hair loss, depression, nausea, and breast pain. Use during pregnancy is not recommended. Use during breastfeeding is likely safe. It works mainly by preventing ovulation.
Estradiol cypionate/medroxyprogesterone acetate came into medical use in 1993 with approval in the United States in 2000. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. It is used in Mexico, Thailand and Indonesia among other countries. It is no longer commercially available in the United States.
- Humans, IARC Working Group on the Evaluation of Carcinogenic Risks to; Organization, World Health; Cancer, International Agency for Research on (2007). Combined Estrogen-progestogen Contraceptives and Combined Estrogen-progestogen Menopausal Therapy. World Health Organization. p. 431. ISBN 9789283212911.
- "Estradiol and medroxyprogesterone Intramuscular Advanced Patient Information - Drugs.com". www.drugs.com. Retrieved 1 January 2017.
- WHO Model Formulary 2008 (PDF). World Health Organization. 2009. pp. 368–370. ISBN 9789241547659. Retrieved 8 December 2016.
- "Estradiol/medroxyprogesterone Side Effects in Detail - Drugs.com". www.drugs.com. Retrieved 1 January 2017.
- "Estradiol / medroxyprogesterone (Lunelle) Use During Pregnancy". www.drugs.com. Retrieved 1 January 2017.
- Senanayake, Pramilla; Potts, Malcolm (2008). Atlas of Contraception, Second Edition (2 ed.). CRC Press. p. 51. ISBN 9780203347324.
- "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Retrieved 8 December 2016.