Isoliquiritigenin 2'-O-methyltransferase

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Isoliquiritigenin 2'-O-methyltransferase
Identifiers
EC number 2.1.1.154
CAS number 139317-14-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

In enzymology, an isoliquiritigenin 2'-O-methyltransferase (EC 2.1.1.154) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + isoliquiritigenin S-adenosyl-L-homocysteine + 2'-O-methylisoliquiritigenin

Thus, the two substrates of this enzyme are S-adenosyl methionine and isoliquiritigenin, whereas its two products are S-adenosylhomocysteine and 2'-O-methylisoliquiritigenin.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:isoliquiritigenin 2'-O-methyltransferase. Other names in common use include chalcone OMT, and CHMT.

References[edit]

  • Maxwell CA, Edwards R, Dixon RA (1992). "Identification, purification, and characterization of S-adenosyl-L-methionine: isoliquiritigenin 2'-O-methyltransferase from alfalfa (Medicago sativa L.)". Arch. Biochem. Biophys. 293 (1): 158–66. doi:10.1016/0003-9861(92)90379-B. PMID 1731632. 
  • Ichimura M, Furuno T, Takahashi T, Dixon RA, Ayabe S (1997). "Enzymic O-methylation of isoliquiritigenin and licodione in alfalfa and licorice cultures". Phytochemistry. 44 (6): 991–5. doi:10.1016/S0031-9422(96)00670-X. PMID 9055445.