List of Hot R&B Sides number ones of 1959
These are the Billboard magazine R&B singles chart number one hits of 1959:
See also: 1959 in music, List of number-one R&B hits (United States)
| Issue Date | Song | Artist |
| January 5 | "Lonely Teardrops" | Jackie Wilson |
| January 12 | "Lonely Teardrops" | Jackie Wilson |
| January 19 | "Lonely Teardrops" | Jackie Wilson |
| January 26 | "Lonely Teardrops" | Jackie Wilson |
| February 2 | "Try Me" | James Brown and His Famous Flames |
| February 9 | "Stagger Lee" | Lloyd Price |
| February 16 | "Stagger Lee" | Lloyd Price |
| February 23 | "Stagger Lee" | Lloyd Price |
| March 2 | ""Stagger Lee" | Lloyd Price |
| March 9 | "It's Just a Matter of Time" | Brook Benton |
| March 16 | "It's Just a Matter of Time" | Brook Benton |
| March 23 | "It's Just a Matter of Time" | Brook Benton |
| March 30 | "It's Just a Matter of Time" | Brook Benton |
| April 6 | "It's Just a Matter of Time" | Brook Benton |
| April 13 | "It's Just a Matter of Time" | Brook Benton |
| April 20 | "It's Just a Matter of Time" | Brook Benton |
| April 27 | "It's Just a Matter of Time" | Brook Benton |
| May 4 | "It's Just a Matter of Time" | Brook Benton |
| May 11 | "Kansas City" | Wilbert Harrison |
| May 18 | "Kansas City" | Wilbert Harrison |
| May 25 | "Kansas City" | Wilbert Harrison |
| June 1 | "Kansas City" | Wilbert Harrison |
| June 8 | "Kansas City" | Wilbert Harrison |
| June 15 | "Kansas City" | Wilbert Harrison |
| June 22 | "Kansas City" | Wilbert Harrison |
| June 29 | "Personality" | Lloyd Price |
| July 6 | "Personality" | Lloyd Price |
| July 13 | "Personality" | Lloyd Price |
| July 20 | "Personality" | Lloyd Price |
| July 27 | "There Goes My Baby" | The Drifters |
| August 3 | "What'd I Say (Part 1)" | Ray Charles |
| August 10 | "Thank You Pretty Baby" | Brook Benton |
| August 17 | "Thank You Pretty Baby" | Brook Benton |
| August 24 | "Thank You Pretty Baby" | Brook Benton |
| August 31 | "Thank You Pretty Baby" | Brook Benton |
| September 7 | I'm Gonna Get Married | Lloyd Price |
| September 14 | I'm Gonna Get Married | Lloyd Price |
| September 21 | "I Want to Walk You Home" | Fats Domino |
| September 28 | "I'm Gonna Get Married" | Lloyd Price |
| October 5 | "Poison Ivy" | The Coasters |
| October 12 | "Sea of Love" | Phil Phillips |
| October 19 | "You Better Know It" | Jackie Wilson |
| October 26 | "Poison Ivy" | The Coasters |
| November 2 | "Poison Ivy" | The Coasters |
| November 9 | "Poison Ivy" | The Coasters |
| November 16 | "So Many Ways" | Brook Benton |
| November 23 | "Don't You Know?" | Della Reese |
| November 30 | "Don't You Know" | Della Reese |
| December 7 | "The Clouds" | The Spacemen |
| December 14 | "So Many Ways" | Brook Benton |
| December 21 | "So Many Ways" | Brook Benton |
| December 28 | "The Clouds" | The Spacemen |