MAPEG family

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MAPEG family
Protein LTC4S PDB 2PNO.png
Crystal structure of human leukotriene C4 synthase. [1]
Identifiers
Symbol MAPEG
Pfam PF01124
InterPro IPR001129
PROSITE PS01297
SCOP 2pno
SUPERFAMILY 2pno
OPM superfamily 199
OPM protein 4yl3

In molecular biology the MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family of proteins are a group of membrane associated proteins with highly divergent functions.[2] Included are the 5-lipoxygenase-activating protein (gene FLAP), leukotriene C4 synthase (EC 2.5.1.37), which catalyzes the production of leukotriene C4 (LTC4) from leukotriene A4 (LTA4), and microsomal glutathione S-transferase II (EC 2.5.1.18) (GST-II), which also produces LTC4 from LTA4.

Another example is prostaglandin E synthase. This enzyme catalyses the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase, and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.

Subfamilies[edit]

Human proteins containing this domain[edit]

References[edit]

  1. ^ Ago, H.; Kanaoka, Y.; Irikura, D.; Lam, B. K.; Shimamura, T.; Austen, K. F.; Miyano, M. (2007). "Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis". Nature. 448 (7153): 609–612. doi:10.1038/nature05936. PMID 17632548. 
  2. ^ Jakobsson, P. J.; Morgenstern, R.; Mancini, J.; Ford-Hutchinson, A.; Persson, B. (2008). "Common structural features of mapeg-a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism". Protein Science. 8 (3): 689–692. doi:10.1110/ps.8.3.689. PMC 2144274Freely accessible. PMID 10091672. 

This article incorporates text from the public domain Pfam and InterPro IPR001129