MAPEG family

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	2PNO

MAPEG family
MAPEG family
	Crystal structure of human leukotriene C4 synthase.
Identifiers
Symbol	MAPEG
Pfam	PF01124
InterPro	IPR001129
PROSITE	PS01297
SCOP2	2pno / SCOPe / SUPFAM
OPM superfamily	178
OPM protein	4yl3
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	2PNO

In molecular biology the MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family of proteins are a group of membrane associated proteins with highly divergent functions.^[2] Included are the 5-lipoxygenase-activating protein (gene FLAP), leukotriene C4 synthase (EC 2.5.1.37), which catalyzes the production of leukotriene C4 (LTC4) from leukotriene A4 (LTA4), and microsomal glutathione S-transferase II (EC 2.5.1.18) (GST-II), which also produces LTC4 from LTA4.

Another example is prostaglandin E synthase. This enzyme catalyses the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase, and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.

Subfamilies

5-lipoxygenase-activating protein InterPro: IPR001129

Human proteins containing this domain

5-lipoxygenase-activating protein (ALOX5AP))
LTC4S
MGST1
MGST2
MGST3
PTGES

References

^ Ago H, Kanaoka Y, Irikura D, Lam BK, Shimamura T, Austen KF, Miyano M (August 2007). "Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis". Nature. 448 (7153): 609–12. Bibcode:2007Natur.448..609A. doi:10.1038/nature05936. PMID 17632548. S2CID 4324979.
^ Jakobsson PJ, Morgenstern R, Mancini J, Ford-Hutchinson A, Persson B (March 1999). "Common structural features of MAPEG -- a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism". Protein Science. 8 (3): 689–92. doi:10.1110/ps.8.3.689. PMC 2144274. PMID 10091672.

This article incorporates text from the public domain Pfam and InterPro: IPR001129

[10.1038/nature05936-1] Ago H, Kanaoka Y, Irikura D, Lam BK, Shimamura T, Austen KF, Miyano M (August 2007). "Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis". Nature. 448 (7153): 609–12. Bibcode:2007Natur.448..609A. doi:10.1038/nature05936. PMID 17632548. S2CID 4324979.

[PUB00005060-2] Jakobsson PJ, Morgenstern R, Mancini J, Ford-Hutchinson A, Persson B (March 1999). "Common structural features of MAPEG -- a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism". Protein Science. 8 (3): 689–92. doi:10.1110/ps.8.3.689. PMC 2144274. PMID 10091672.

[1]

[2]