Leukotriene C4 synthase

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LTC4S
Protein LTC4S PDB 2PNO.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases LTC4S, entrez:4056, Leukotriene C4 synthase
External IDs OMIM: 246530 MGI: 107498 HomoloGene: 7406 GeneCards: LTC4S
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_145867

NM_008521
NM_001313968

RefSeq (protein)

NP_665874

NP_032547.1
NP_001300897
NP_032547

Location (UCSC) Chr 5: 179.79 – 179.8 Mb Chr 11: 50.24 – 50.24 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Leukotriene C4 synthase is an enzyme that in humans is encoded by the LTC4S gene.[3][4]

The protein encoded by this gene, LTC4S (or glutathione S-transferase II) is an enzyme that converts leukotriene A4 and glutathione to create leukotriene C4. This is a member of MAPEG family of transmembrane proteins. A trimer of Leukotriene C4 synthase is localized on the outer nuclear membrane and endoplasmic reticulum, where it forms a complex with 5-Lipoxygenase-activating protein. This protein is remotely related to microsomal glutathione S-transferase.

Function[edit]

The MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum.[4]

Eicosanoid synthesis. (Leukotrienes at right.)

References[edit]

Further reading[edit]

External links[edit]