Microsomal glutathione S-transferase 1

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MGST1
Identifiers
Aliases MGST1, GST12, MGST, MGST-I, microsomal glutathione S-transferase 1
External IDs MGI: 1913850 HomoloGene: 10544 GeneCards: MGST1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_019946
NM_001347489

RefSeq (protein)

NP_064330.2
NP_001334418
NP_064330

Location (UCSC) Chr 12: 16.35 – 16.61 Mb Chr 6: 138.14 – 138.16 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Microsomal glutathione S-transferase 1 is an enzyme that in humans is encoded by the MGST1 gene.[3]

Function[edit]

The MAPEG family (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Four transcript variants of this gene encode one protein isoform.[3]

References[edit]

Further reading[edit]