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Available structures
PDBOrtholog search: PDBe RCSB
AliasesMAPK8IP3, JIP3, JSAP1, SYD2, syd, JIP-3, mitogen-activated protein kinase 8 interacting protein 3
External IDsMGI: 1353598 HomoloGene: 22790 GeneCards: MAPK8IP3
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for MAPK8IP3
Genomic location for MAPK8IP3
Band16p13.3Start1,706,183 bp[1]
End1,770,317 bp[1]
RNA expression pattern
PBB GE MAPK8IP3 216139 s at fs.png

PBB GE MAPK8IP3 213177 at fs.png

PBB GE MAPK8IP3 213178 s at fs.png
More reference expression data
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC)Chr 16: 1.71 – 1.77 MbChr 17: 24.89 – 24.94 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

C-jun-amino-terminal kinase-interacting protein 3 is an enzyme that in humans is encoded by the MAPK8IP3 gene.[5][6][7]

The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[7]


MAPK8IP3 has been shown to interact with ASK1,[8] C-Raf,[5][9] PTK2,[10] MAPK10,[5][6][8] Mitogen-activated protein kinase 9,[5][6] MAPK8,[5][6] MAP2K1,[5][9] KLC2,[11] MAP2K7,[6][8] KLC1,[11] MAPK8IP2[6] and MAP2K4.[5][8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138834 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024163 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b c d e f g Ito M, Yoshioka K, Akechi M, Yamashita S, Takamatsu N, Sugiyama K, Hibi M, Nakabeppu Y, Shiba T, Yamamoto KI (November 1999). "JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway". Mol Cell Biol. 19 (11): 7539–48. doi:10.1128/mcb.19.11.7539. PMC 84763Freely accessible. PMID 10523642. 
  6. ^ a b c d e f Kelkar N, Gupta S, Dickens M, Davis RJ (February 2000). "Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3". Mol Cell Biol. 20 (3): 1030–43. doi:10.1128/MCB.20.3.1030-1043.2000. PMC 85220Freely accessible. PMID 10629060. 
  7. ^ a b "Entrez Gene: MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3". 
  8. ^ a b c d Matsuura, Hiroshi; Nishitoh Hideki; Takeda Kohsuke; Matsuzawa Atsushi; Amagasa Teruo; Ito Michihiko; Yoshioka Katsuji; Ichijo Hidenori (October 2002). "Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade". J. Biol. Chem. United States. 277 (43): 40703–9. doi:10.1074/jbc.M202004200. ISSN 0021-9258. PMID 12189133. 
  9. ^ a b Kuboki, Y; Ito M; Takamatsu N; Yamamoto K I; Shiba T; Yoshioka K (December 2000). "A scaffold protein in the c-Jun NH2-terminal kinase signaling pathways suppresses the extracellular signal-regulated kinase signaling pathways". J. Biol. Chem. UNITED STATES. 275 (51): 39815–8. doi:10.1074/jbc.C000403200. ISSN 0021-9258. PMID 11044439. 
  10. ^ Takino, Takahisa; Yoshioka Katsuji; Miyamori Hisashi; Yamada Kenneth M; Sato Hiroshi (September 2002). "A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated". Oncogene. England. 21 (42): 6488–97. doi:10.1038/sj.onc.1205840. ISSN 0950-9232. PMID 12226752. 
  11. ^ a b Bowman, A B; Kamal A; Ritchings B W; Philp A V; McGrail M; Gindhart J G; Goldstein L S (November 2000). "Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein". Cell. UNITED STATES. 103 (4): 583–94. doi:10.1016/S0092-8674(00)00162-8. ISSN 0092-8674. PMID 11106729. 

Further reading[edit]