MDFI

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MDFI
Identifiers
Aliases MDFI, MyoD family inhibitor, I-MF, I-mfa
External IDs MGI: 107687 HomoloGene: 21150 GeneCards: MDFI
RNA expression pattern
PBB GE MDFI 205375 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001300804
NM_001300805
NM_001300806
NM_005586

NM_001109973
NM_001276390
NM_001276391
NM_010783

RefSeq (protein)

NP_001287733
NP_001287734
NP_001287735
NP_005577

Location (UCSC) Chr 6: 41.64 – 41.65 Mb Chr 17: 47.82 – 47.83 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

MyoD family inhibitor is a protein that in humans is encoded by the MDFI gene.[3][4][5]

Function[edit]

This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures.[5]

Interactions[edit]

MDFI has been shown to interact with:

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Kraut N (Sep 1997). "The gene encoding I-mf (Mdfi) maps to human chromosome 6p21 and mouse chromosome 17". Mamm Genome. 8 (8): 618–9. doi:10.1007/s003359900517. PMID 9250874. 
  4. ^ Wang Q, Young TM, Mathews MB, Pe'ery T (Mar 2007). "Developmental regulators containing the I-mfa domain interact with T cyclins and Tat and modulate transcription". J Mol Biol. 367 (3): 630–46. doi:10.1016/j.jmb.2007.01.020. PMC 1868487Freely accessible. PMID 17289077. 
  5. ^ a b "Entrez Gene: MDFI MyoD family inhibitor". 
  6. ^ a b c Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  7. ^ a b Chen CM, Kraut N, Groudine M, Weintraub H (Sep 1996). "I-mf, a novel myogenic repressor, interacts with members of the MyoD family". Cell. 86 (5): 731–41. doi:10.1016/s0092-8674(00)80148-8. PMID 8797820. 

Further reading[edit]