MIS18 binding protein 1 is a protein that in humans is encoded by the MIS18BP1gene.[5][6][7] The gene is also known as LKNL2, M18BP1, C14orf106, and HSA242977.[5]
Model organisms have been used in the study of MIS18BP1 function. A conditional knockout mouse line, called Mis18bp1tm1a(EUCOMM)Wtsi[13] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[14][15][16]
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[11][17] Twenty five tests were carried out on mutant mice and three significant abnormalities were observed.[11] Few homozygousmutant embryos were identified during gestation, and none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice and an abnormal tail morphology was observed in female animals.[11]
^Fujita Y, Hayashi T, Kiyomitsu T, Toyoda Y, Kokubu A, Obuse C, Yanagida M (Jan 2007). "Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1". Dev Cell. 12 (1): 17–30. doi:10.1016/j.devcel.2006.11.002. PMID17199038.
^ abcdGerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
Fujita Y, Hayashi T, Kiyomitsu T, Toyoda Y, Kokubu A, Obuse C, Yanagida M (January 2007). "Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1". Dev. Cell. 12 (1): 17–30. doi:10.1016/j.devcel.2006.11.002. PMID17199038.
