MT-CYB

CYTB
Identifiers
Aliases	CYTB, MTCYB, MT-CYB, cytochrome b
External IDs	OMIM: 516020; MGI: 102501; HomoloGene: 5013; GeneCards: CYTB; OMA:CYTB - orthologs
Gene location (Human) Chr. Mitochondrial DNA (human) Band n/a Start 14,747 bp End 15,887 bp
Gene location (Mouse) Chr. Mitochondrial DNA (mouse) Band n/a Start 14,145 bp End 15,288 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart gastric mucosa right lobe of thyroid gland left ventricle putamen caudate nucleus left uterine tube nucleus accumbens subcutaneous adipose tissue right adrenal cortex Top expressed in neural layer of retina hypothalamus striatum of neuraxis adrenal gland dentate gyrus of hippocampal formation granule cell right kidney primary visual cortex superior frontal gyrus cerebellum cerebellar cortex More reference expression data BioGPS n/a
Gene ontology Molecular function ubiquinol-cytochrome-c reductase activity protein-containing complex binding metal ion binding electron transfer activity oxidoreductase activity heme binding Cellular component mitochondrial respiratory chain complex III integral component of membrane respiratory chain complex III membrane mitochondrion mitochondrial inner membrane respirasome integral component of mitochondrial inner membrane protein-containing complex Biological process response to hypoxia response to glucagon response to cadmium ion response to organic cyclic compound response to nutrient response to copper ion response to hyperoxia hyperosmotic salinity response response to heat response to calcium ion animal organ regeneration response to organonitrogen compound response to hormone response to mercury ion response to ethanol response to toxic substance response to cobalamin proton transmembrane transport respiratory electron transport chain mitochondrial electron transport, ubiquinol to cytochrome c electron transport coupled proton transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4519 17711 Ensembl ENSG00000198727 ENSMUSG00000064370 UniProt P00156 P00158 RefSeq (mRNA) n/a n/a RefSeq (protein) n/a NP_904340 Location (UCSC) Chr M: 0.01 – 0.02 Mb Chr M: 0.01 – 0.02 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Location of the MT-CYB gene in the human mitochondrial genome (coral box).

Cytochrome b is a protein that in humans is encoded by the MT-CYB gene.

Its gene product is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex), which consists of the products of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b) and ten nuclear genes: UQCRC1, UQCRC2, Cytochrome c1, UQCRFS1 (Rieske protein), UQCRB, "11kDa protein", UQCRH (cyt c1 Hinge protein), Rieske Protein presequence, "cyt. c1 associated protein", and Rieske-associated protein.

Further reading

• Ingman M, Kaessmann H, Pääbo S, Gyllensten U (Dec 2000). "Mitochondrial genome variation and the origin of modern humans". Nature. 408 (6813): 708–13. doi:10.1038/35047064. PMID 11130070.
• Maca-Meyer N, González AM, Larruga JM, Flores C, Cabrera VM (2003). "Major genomic mitochondrial lineages delineate early human expansions". BMC Genetics. 2: 13. doi:10.1186/1471-2156-2-13. PMC 55343. PMID 11553319.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Herrnstadt C, Elson JL, Fahy E, Preston G, Turnbull DM, Anderson C, Ghosh SS, Olefsky JM, Beal MF, Davis RE, Howell N (May 2002). "Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups". American Journal of Human Genetics. 70 (5): 1152–71. doi:10.1086/339933. PMC 447592. PMID 11938495.
• Silva WA, Bonatto SL, Holanda AJ, Ribeiro-Dos-Santos AK, Paixão BM, Goldman GH, Abe-Sandes K, Rodriguez-Delfin L, Barbosa M, Paçó-Larson ML, Petzl-Erler ML, Valente V, Santos SE, Zago MA (Jul 2002). "Mitochondrial genome diversity of Native Americans supports a single early entry of founder populations into America". American Journal of Human Genetics. 71 (1): 187–92. doi:10.1086/341358. PMC 384978. PMID 12022039.
• Yamasoba T, Goto Yi, Oka Y, Nishino I, Tsukuda K, Nonaka I (Jun 2002). "Atypical muscle pathology and a survey of cis-mutations in deaf patients harboring a 1555 A-to-G point mutation in the mitochondrial ribosomal RNA gene". Neuromuscular Disorders. 12 (5): 506–12. doi:10.1016/S0960-8966(01)00329-7. PMID 12031626.
• Mishmar D, Ruiz-Pesini E, Golik P, Macaulay V, Clark AG, Hosseini S, Brandon M, Easley K, Chen E, Brown MD, Sukernik RI, Olckers A, Wallace DC (Jan 2003). "Natural selection shaped regional mtDNA variation in humans". Proceedings of the National Academy of Sciences of the United States of America. 100 (1): 171–6. doi:10.1073/pnas.0136972100. PMC 140917. PMID 12509511.
• Mancuso M, Filosto M, Stevens JC, Patterson M, Shanske S, Krishna S, DiMauro S (May 2003). "Mitochondrial myopathy and complex III deficiency in a patient with a new stop-codon mutation (G339X) in the cytochrome b gene". Journal of the Neurological Sciences. 209 (1–2): 61–3. doi:10.1016/S0022-510X(02)00462-8. PMID 12686403.
• Ingman M, Gyllensten U (Jul 2003). "Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines". Genome Research. 13 (7): 1600–6. doi:10.1101/gr.686603. PMC 403733. PMID 12840039.
• Kong QP, Yao YG, Sun C, Bandelt HJ, Zhu CL, Zhang YP (Sep 2003). "Phylogeny of east Asian mitochondrial DNA lineages inferred from complete sequences". American Journal of Human Genetics. 73 (3): 671–6. doi:10.1086/377718. PMC 1180693. PMID 12870132.
• Kong QP, Yao YG, Liu M, Shen SP, Chen C, Zhu CL, Palanichamy MG, Zhang YP (Oct 2003). "Mitochondrial DNA sequence polymorphisms of five ethnic populations from northern China". Human Genetics. 113 (5): 391–405. doi:10.1007/s00439-003-1004-7. PMID 12938036.
• Maca-Meyer N, González AM, Pestano J, Flores C, Larruga JM, Cabrera VM (Oct 2003). "Mitochondrial DNA transit between West Asia and North Africa inferred from U6 phylogeography". BMC Genetics. 4: 15. doi:10.1186/1471-2156-4-15. PMC 270091. PMID 14563219.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Haut S, de Villemeur TB, Brivet M, Guiochon-Mantel A, Boutron A, Rustin P, Legrand A, Slama A (Mar 2004). "The deleterious G15498A mutation in mitochondrial DNA-encoded cytochrome b may remain clinically silent in homoplasmic carriers". European Journal of Human Genetics. 12 (3): 220–4. doi:10.1038/sj.ejhg.5201132. PMID 14735157.
• Palanichamy MG, Sun C, Agrawal S, Bandelt HJ, Kong QP, Khan F, Wang CY, Chaudhuri TK, Palla V, Zhang YP (Dec 2004). "Phylogeny of mitochondrial DNA macrohaplogroup N in India, based on complete sequencing: implications for the peopling of South Asia". American Journal of Human Genetics. 75 (6): 966–78. doi:10.1086/425871. PMC 1182158. PMID 15467980.
• Starikovskaya EB, Sukernik RI, Derbeneva OA, Volodko NV, Ruiz-Pesini E, Torroni A, Brown MD, Lott MT, Hosseini SH, Huoponen K, Wallace DC (Jan 2005). "Mitochondrial DNA diversity in indigenous populations of the southern extent of Siberia, and the origins of Native American haplogroups". Annals of Human Genetics. 69 (Pt 1): 67–89. doi:10.1046/j.1529-8817.2003.00127.x. PMC 3905771. PMID 15638829.
• Rajkumar R, Banerjee J, Gunturi HB, Trivedi R, Kashyap VK (2006). "Phylogeny and antiquity of M macrohaplogroup inferred from complete mt DNA sequence of Indian specific lineages". BMC Evolutionary Biology. 5: 26. doi:10.1186/1471-2148-5-26. PMC 1079809. PMID 15804362.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Thangaraj K, Chaubey G, Kivisild T, Reddy AG, Singh VK, Rasalkar AA, Singh L (May 2005). "Reconstructing the origin of Andaman Islanders". Science. 308 (5724): 996. doi:10.1126/science.1109987. PMID 15890876.
• Blakely EL, Mitchell AL, Fisher N, Meunier B, Nijtmans LG, Schaefer AM, Jackson MJ, Turnbull DM, Taylor RW (Jul 2005). "A mitochondrial cytochrome b mutation causing severe respiratory chain enzyme deficiency in humans and yeast". The FEBS Journal. 272 (14): 3583–92. doi:10.1111/j.1742-4658.2005.04779.x. PMID 16008558.
• Kivisild T, Shen P, Wall DP, Do B, Sung R, Davis K, Passarino G, Underhill PA, Scharfe C, Torroni A, Scozzari R, Modiano D, Coppa A, de Knijff P, Feldman M, Cavalli-Sforza LL, Oefner PJ (Jan 2006). "The role of selection in the evolution of human mitochondrial genomes". Genetics. 172 (1): 373–87. doi:10.1534/genetics.105.043901. PMC 1456165. PMID 16172508.
• Behar DM, Metspalu E, Kivisild T, Achilli A, Hadid Y, Tzur S, Pereira L, Amorim A, Quintana-Murci L, Majamaa K, Herrnstadt C, Howell N, Balanovsky O, Kutuev I, Pshenichnov A, Gurwitz D, Bonne-Tamir B, Torroni A, Villems R, Skorecki K (Mar 2006). "The matrilineal ancestry of Ashkenazi Jewry: portrait of a recent founder event". American Journal of Human Genetics. 78 (3): 487–97. doi:10.1086/500307. PMC 1380291. PMID 16404693.
• van Holst Pellekaan SM, Ingman M, Roberts-Thomson J, Harding RM (Oct 2006). "Mitochondrial genomics identifies major haplogroups in Aboriginal Australians". American Journal of Physical Anthropology. 131 (2): 282–94. doi:10.1002/ajpa.20426. PMID 16596590.