In 2005 Strong was selected to his first NFL Pro Bowl and chosen as an Associated Press All-Pro. He was known as one of the best blocking fullbacks in the NFL. Strong was again selected to the Pro Bowl in 2006.
In the 2007 season Strong suffered a herniated disk in his neck that was causing trauma to his spinal cord against the Pittsburgh Steelers. The injury was said not to be paralysis threatening if Strong discontinued his playing of football. On October 8, 2007, Strong announced his retirement after 15 seasons due to this injury. After discussions with head coachMike Holmgren, he was able to take on a position assisting the team's running backs. While being interviewed on Monday Night Football on November 12, 2007 he hinted at a possible future in the broadcast booth. Mack and his wife, Zoe, devote their time to working with the Washington Chapter of HOPE worldwide, a non-profit organization. Mack is a founder of their signature program in Washington state, the Mack Strong TEAM-WORKS Academy.
On July 30, 2008, Fox Sports Northwest announced that Strong would be joining the network's talent team. In addition to providing insight and commentary on FSN's Seahawks coverage, he also was given his own show, titled "Mack Strong: Seahawks Insider".