Allegedly recruited by 350 colleges, Easley selected UCLA for his college football career. He started 10 games his freshman year, recording nine interceptions and was named to his first all Pac-10 squad. Later, he became the first player in conference history to be honored as all-conference for four consecutive years. Playing from 1977 to 1980, Easley finished his college career with a school-record nineteen interceptions and 324 tackles. Easley was selected as a three-time consensus All-American selection—(1978, 1979, and 1980) and finished ninth in the Heisman Trophy balloting in 1980. His jersey number was retired by the school, and in 1991 he was elected to the UCLA Athletic Hall of Fame and the College Football Hall of Fame. He also played basketball at the junior varsity level for UCLA and was drafted by the Chicago Bulls in the tenth round of the 1981 NBA Draft but did not play.
Easley was selected as the fourth overall pick in the first round of the 1981 NFL Draft by the Seattle Seahawks. He became an immediate starter as a rookie, recording three interceptions for 155 yards and one touchdown, earning him AFC Defensive Rookie of the Year honors. In 1983, the Seahawks hired former Buffalo Bills coach Chuck Knox as their head coach and Easley immediately became the "backbone" of Knox's defense. In his first season playing for Knox, Easley won the AFC Defensive Player of the Year Award and recorded seven interceptions. In 1984, Easley led the NFL in interceptions with ten, which tied a club record. He returned two of them for touchdowns and was named as the NFL Defensive Player of the Year, the first safety awarded since Dick Anderson in 1973. On November 4, 1984, during a 45–0 win against the Kansas City Chiefs, the Seahawks returned four interceptions for touchdowns, including one caught by Easley, breaking the record for most touchdowns scored from an interception in a game. He also took over the role of the team's main punt returner when Paul Johns got injured earlier in the season.
After the season, Easley signed a five-year contract to stay with the Seahawks, averaging $650,000 a year plus incentives. The contract made him one of the highest paid defensive players in the league. In 1985, Easley was selected for his fourth consecutive Pro Bowl, a team record until defensive tackleCortez Kennedy was selected for his fifth consecutive Pro Bowl in 1995.
He obviously is either desperate to play in the NFL or desperate for money. Here's a guy who played in the NFL for a long time and who was adored and was admired by his fans and teammates. Now, he turns his back on us.
Easley also warned his fellow players that he was against the idea of using violence against the replacement players in order to prove a point. Once the strike ended, Easley had an off-year as the Seahawks passing defense fell to 25th in the league. His last game was a 23–20 loss against the Houston Oilers during the 1987 NFL playoffs in overtime.
Prior to the 1988 season, the Seahawks offered Easley to several clubs in an attempt to get a quarterback in return. Easley's declining play, which was partially blamed on his work during the strike, and the blossoming of Easley's backup Paul Moyer, had made Easley expendable. On April 22, 1988, the Seahawks traded Easley to the Phoenix Cardinals for quarterback Kelly Stouffer. During the mandatory team physical, Easley was diagnosed with idiopathic nephrotic syndrome, a severe kidney disease that voided the trade. Easley had told Moyer that he thought his days with the Seahawks were numbered because of his involvement in the player's strike. He was not surprised when the trade happened, but the kidney diagnosis had "shocked" him. The Seahawks offered several draft picks as compensation to the Cardinals to complete the trade, and Easley announced his retirement a few months later.
Easley filed a lawsuit against the Seahawks, their team trainer, and the team doctors stating that an overdose of Advil (ibuprofen) for an ankle injury a few years before was the cause of his kidney failure. He knew as early as 1986 that there were issues with his kidney, but finally realized the severity of it when he failed the Cardinals physical. Easley claimed that he took 15 to 20 Advil's daily for three months to reduce the swelling in his ankle, before a doctor interfered and told him to stop. A former teammate said that Advil and other medications were easily obtainable in the Seahawks locker room in "large dispensers" without proper medical supervision. Easley's physicians claimed that they never told him to take the quantity of Advil's Easley claimed he took. His case made national headlines and formed discussion involving the safe use of over the counter medication like Advil. The lawsuit was later settled out of court.
Easley received a new kidney two years later at the University of Washington Medical Center. After his retirement Easley cut most of his ties with the Seahawks organization, citing the lawsuit, how his "dignity" was affected by the Stouffer trade, and how no one from the organization offered condolences after his transplant.
In 1991, Easley bought into a car dealership (along with partner Rick Johnson), Alderwood Oldsmobile & Cadillac in Lynnwood Washington, (which later moved to Shoreline, Washington in 1996, taking advantage of a General Motors program that made it easier for African-Americans and other minorities to own an auto dealership. The dealership became successful and Easley was named president of the African American Dealers Association.
In 1999, Easley, along with Buffalo Bills defensive end Bruce Smith, were named as the new owners of the Norfolk Nighthawks of the AF2, a semi-professional arena football league branched out from the Arena Football League. The day after the city announced Easley and Smith as owners, a controversy arose with Mark Garcea and Page Johnson, the owners of the Hampton Roads Admirals minor league hockey team, and the city of Norfolk, Virginia. Garcea and Johnson stated that they participated in the original AF2 meetings and asked the city for exclusive rights to own the franchise, providing a $5,000 down payment. Instead, the city allowed Easley and Smith to pay the league's $75,000 franchise fee. The AF2 started playing their first games in the summer of 2000. In his first season as owner, the Nighthawks averaged 6,500 fans at their home field per game, and sold 3,200 season tickets. The team made the AF2 playoffs, but lost money in their first season, which Easley blamed as "rookie mistakes" and startup costs. The team disbanded prior to the 2004 season.
In his seven-year career, Easley recorded 32 interceptions for 538 yards and three touchdowns, while also returning 27 punts for 302 yards. In 2002, Easley was elected to the Seattle Seahawks Ring of Honor after several attempts by the Seahawks to nominate him, but he was not interested. He was also named to the NFL 1980s All-Decade Team.