Magaldrate

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Magaldrate
Magaldrate.png
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
MedlinePlus a682683
Pregnancy
category
  • C
Routes of
administration
Oral
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability Negligible
Metabolism Nil
Excretion Fecal and renal
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
Formula AlMg2(OH)7·H2O
Molar mass 212.66 g/mol
  (verify)

Magaldrate (INN) is a common antacid drug that is used for the treatment of duodenal and gastric ulcers, esophagitis from gastroesophageal reflux.

Available forms[edit]

Magaldrate is available in the form of oral suspension or tablets.

Pharmacology[edit]

Magaldrate is a hydroxymagnesium aluminate complex that is converted rapidly in gastric acid to Mg(OH)2 and Al(OH)3, which are absorbed poorly and thus provide a sustained antacid effect.[1]

Interactions and adverse reactions[edit]

Magaldrate may negatively influence drugs like tetracyclines, benzodiazepines, and indomethacin. High doses or prolonged usage may lead to an increment of defecation and a reduction in feces consistence. In some cases it can alter the functionality of the gastrointestinal tract, occasionally provoking constipation or diarrhea.

References[edit]

  1. ^ Laurence L., Brunton. Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12th ed.