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proopiomelanocortin derivatives
γ-MSH ACTH β-lipotropin
  α-MSH CLIP γ-lipotropin β-endorphin

The melanocortins are a group of peptide hormones which include adrenocorticotropic hormone (ACTH) and the different forms of melanocyte-stimulating hormone (MSH),[1] and are derived from proopiomelanocortin (POMC) in the pituitary gland.[2] The melanocortins exert their effects by binding to and activating the melanocortin receptors.[1]


  1. ^ a b Gantz I, Fong TM (March 2003). "The melanocortin system". Am. J. Physiol. Endocrinol. Metab. 284 (3): E468–74. PMID 12556347. doi:10.1152/ajpendo.00434.2002. 
  2. ^ Raffin-Sanson ML, de Keyzer Y, Bertagna X (August 2003). "Proopiomelanocortin, a polypeptide precursor with multiple functions: from physiology to pathological conditions". Eur. J. Endocrinol. 149 (2): 79–90. PMID 12887283. doi:10.1530/eje.0.1490079. 

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