Methylamine-corrinoid protein Co-methyltransferase
| Methylamine-corrinoid protein Co-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.248 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Methylamine-corrinoid protein Co-methyltransferase (EC 2.1.1.248, mtmB (gene), monomethylamine methyltransferase) is an enzyme with systematic name monomethylamine:5-hydroxybenzimidazolylcobamide Co-methyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction
- methylamine + [Co(I) methylamine-specific corrinoid protein] [methyl-Co(III) methylamine-specific corrinoid protein] + ammonia
This enzyme is involved in methanogenesis from methylamine.
References
- ^ Burke, S.A.; Krzycki, J.A. (1997). "Reconstitution of Monomethylamine:Coenzyme M methyl transfer with a corrinoid protein and two methyltransferases purified from Methanosarcina barkeri". J. Biol. Chem. 272: 16570–16577. doi:10.1074/jbc.272.26.16570. PMID 9195968.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Burke, S.A.; Lo, S.L.; Krzycki, J.A. (1998). "Clustered genes encoding the methyltransferases of methanogenesis from monomethylamine". J. Bacteriol. 180: 3432–3440. PMID 9642198.
- ^ Krzycki, J.A. (2004). "Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases". Curr. Opin. Chem. Biol. 8: 484–491. doi:10.1016/j.cbpa.2004.08.012. PMID 15450490.
External links
- Methylamine---corrinoid+protein+Co-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)