Morin (flavonol)
| |
| |
| Names | |
|---|---|
| IUPAC name
2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one
| |
| Other names
Aurantica
Al-Morin Morin hydrate Calico Yellow Toxylon pomiferum Bois d'arc Osage orange extract | |
| Identifiers | |
3D model (JSmol)
|
|
| ChEBI | |
| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | 100.006.858 |
| KEGG | |
PubChem CID
|
|
CompTox Dashboard (EPA)
|
|
| |
| |
| Properties | |
| C15H10O7 | |
| Molar mass | 302.2357 g/mol |
| Density | 1.799 g/mL |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
| |
Morin is a yellow chemical compound that can be isolated from Maclura pomifera (Osage orange), Maclura tinctoria (old fustic) and from leaves of Psidium guajava (common guava).[1] In a preclinical in vitro study, morin was found to be a weak inhibitor of fatty acid synthase with an IC50 of 2.33 μM.[2] Morin was also found to inhibit amyloid formation by islet amyloid polypeptide (or amylin) and disaggregates amyloid fibers.
Such amyloid formation may have a role in Alzheimer's disease, as well as type 2 diabetes.[3] It may also contribute to graft failure in islet cell transplantation in type 1 diabetes.[3]
Morin can be used to test for the presence of aluminium or tin in a solution, since it forms characteristically fluorescent coordination complexes with them.
Glycosides
- Morin-3-O-arabinoside[1]
- Morin-3-O-lyxoside[1]
References
- ^ a b c Bacteriostatic effect of flavonoids isolated from leaves of Psidium guajava on fish pathogens. Rattanachaikunsopon Pongsak and Phumkhachorn Parichat, INIST 19087798
- ^ Tian, WX (February 2006). "Inhibition of Fatty Acid Synthase by Polyphenols". Current Medicinal Chemistry. 13 (8): 967–977. doi:10.2174/092986706776361012. PMID 16611078.
- ^ a b Noor, H; Cao, P; Raleigh, DP (March 2012). "Morin hydrate inhibits amyloid formation by islet amyloid polypeptide and disaggregates amyloid fibers". Protein science : a publication of the Protein Society. 21 (3): 373–82. PMC 3375438. PMID 22238175.