Gossypetin

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Gossypetin
Skeletal formula of gossypetin
Ball-and-stick model of the gossypetin molecule
Names
IUPAC name
2-(3,4-dihydroxyphenyl)-3,5,7,8-tetrahydroxychromen-4-one
Other names
Articulatidin
Equisporol
3,3',4',5,7,8-Hexahydroxyflavone
3,5,7,8,3',4'-Hexahydroxyflavone
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
Properties
C15H10O8
Molar mass 318.23 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Gossypetin, also known as 3,5,7,8,3',4'-hexahydroxyflavone, is a flavonol, a type of flavonoid. It has been isolated from the flowers and the calyx of Hibiscus sabdariffa (roselle) and exhibits a strong antibacterial activity.[1][2]

Gossypetin has been found to act as an antagonist of TrkB.[3]

Metabolism[edit]

The enzyme 8-hydroxyquercetin 8-O-methyltransferase uses S-adenosyl methionine and gossypetin to produce S-adenosylhomocysteine and 3,5,7,3',4'-pentahydroxy-8-methoxyflavone[citation needed]. Recently it was shown that gossypetin has radioprotective activity[2].

See also[edit]

References[edit]

  1. ^ Antibacterial activity of gossypetin isolated from hibiscus sabdariffa
  2. ^ Amitava Khan, Krishnendu Manna, Chinchubose, Mahuya Sinha, Dipesh Kr Das, Swaraj Bandhu Kesh, Anindita Chakrabarty, Asoke Banerji & Sanjit Dey: Gossypetin, a naturally occurring hexahydroxy flavones ameliorates gamma radiation mediated DNA damage International Journal Of Radiation Biology (2013):89(11): 965-975.
  3. ^ Obianyo, Obiamaka; Ye, Keqiang (2013). "Novel small molecule activators of the Trk family of receptor tyrosine kinases". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1834 (10): 2213–2218. ISSN 1570-9639. doi:10.1016/j.bbapap.2012.08.021.