N,N'-diacetyllegionaminate synthase
| N,N'-diacetyllegionaminate synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.5.1.101 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
N,N'-diacetyllegionaminate synthase (EC 2.5.1.101, neuB (gene), legI (gene)) is an enzyme with systematic name phosphenolpyruvate:2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose 1-(2-carboxy-2-oxoethyl)transferase.[1][2] This enzyme catalyses the following chemical reaction
- 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + phosphenolpyruvate + H2O N,N'-diacetyllegionaminate + phosphate
This enzyme requires a divalent metal such as Mn2+.
References
- ^ Glaze, P.A.; Watson, D.C.; Young, N.M.; Tanner, M.E. (2008). "Biosynthesis of CMP-N,N′-diacetyllegionaminic acid from UDP-N,N′-diacetylbacillosamine in Legionella pneumophila". Biochemistry. 47 (10): 3272–3282. doi:10.1021/bi702364s. PMID 18275154.
- ^ Schoenhofen, I.C.; Vinogradov, E.; Whitfield, D.M.; Brisson, J.R.; Logan, S.M. (2009). "The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors". Glycobiology. 19 (7): 715–725. doi:10.1093/glycob/cwp039. PMID 19282391.
External links
- N,N'-diacetyllegionaminate+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)