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TRNA (guanine10-N2)-dimethyltransferase

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TRNA (guanine10-N2)-dimethyltransferase
Identifiers
EC no.2.1.1.213
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BRENDABRENDA entry
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MetaCycmetabolic pathway
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TRNA (guanine10-N2)-dimethyltransferase (EC 2.1.1.213, PAB1283, N(2),N(2)-dimethylguanosine tRNA methyltransferase, Trm-G10, PabTrm-G10, PabTrm-m2 2G10 enzyme) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine10-N2)-dimethyltransferase.[1] This enzyme catalyses the following chemical reaction

2 S-adenosyl-L-methionine + guanine10 in tRNA 2 S-adenosyl-L-homocysteine + N2-dimethylguanine10 in tRNA (overall reaction)
(1a) S-adenosyl-L-methionine + guanine10 in tRNA S-adenosyl-L-homocysteine + N2-methylguanine10 in tRNA
(1b) S-adenosyl-L-methionine + N2-methylguanine10 in tRNA S-adenosyl-L-homocysteine + N2-dimethylguanine10 in tRNA

References

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  1. ^ Armengaud J, Urbonavicius J, Fernandez B, Chaussinand G, Bujnicki JM, Grosjean H (August 2004). "N2-methylation of guanosine at position 10 in tRNA is catalyzed by a THUMP domain-containing, S-adenosylmethionine-dependent methyltransferase, conserved in Archaea and Eukaryota" (PDF). The Journal of Biological Chemistry. 279 (35): 37142–52. doi:10.1074/jbc.m403845200. PMID 15210688.
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