Site-specific DNA-methyltransferase (cytosine-N4-specific)

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Site-specific DNA-methyltransferase (cytosine-N4-specific)
Identifiers
EC number 2.1.1.113
CAS number 169592-50-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Site-specific DNA-methyltransferase (cytosine-N4-specific) (EC 2.1.1.113, modification methylase, restriction-modification system, DNA[cytosine-N4]methyltransferase, m4C-forming MTase, S-adenosyl-L-methionine:DNA-cytosine 4-N-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:DNA-cytosine N4-methyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + DNA cytosine S-adenosyl-L-homocysteine + DNA N4-methylcytosine

This is a large group of enzymes.[5]

See also[edit]

References[edit]

  1. ^ Kessler C, Manta V (August 1990). "Specificity of restriction endonucleases and DNA modification methyltransferases a review (Edition 3)". Gene. 92 (1-2): 1–248. doi:10.1016/0378-1119(90)90486-B. PMID 2172084. 
  2. ^ Klimasauskas S, Timinskas A, Menkevicius S, Butkienè D, Butkus V, Janulaitis A (December 1989). "Sequence motifs characteristic of DNA[cytosine-N4]methyltransferases: similarity to adenine and cytosine-C5 DNA-methylases". Nucleic Acids Research. 17 (23): 9823–32. doi:10.1093/nar/17.23.9823. PMC 335216Freely accessible. PMID 2690010. 
  3. ^ Roberts RJ (April 1990). "Restriction enzymes and their isoschizomers". Nucleic Acids Research. 18 Suppl: 2331–65. doi:10.1093/nar/18.suppl.2331. PMC 331877Freely accessible. PMID 2159140. 
  4. ^ Yuan R (1981). "Structure and mechanism of multifunctional restriction endonucleases". Annual Review of Biochemistry. 50: 285–319. doi:10.1146/annurev.bi.50.070181.001441. PMID 6267988. 
  5. ^ Roberts RJ. "A complete listing of all of these enzymes". The Restriction Enzyme Database. 

External links[edit]