The full gene is 75,313 bp, with the major isoform of mRNA being 10,697 bp long. The gene is located at 1q21.1. NBPF contains what is known as the DUF1220 repeats. The highly conserved, repeated region is believed to be originated from MGC8902. The NBPF family has been linked to primate evolution. It is assumed to be related to the 1q21.1 deletion syndrome and 1q21.1 duplication syndrome.
^ abVandepoele K, Van Roy N, Staes K, Speleman F, van Roy F (November 2005). "A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution". Mol. Biol. Evol. 22 (11): 2265–74. doi:10.1093/molbev/msi222. PMID16079250.
^e.g.: L. Dumas and J.M. Sikela; DUF1220 Domains, Cognitive Disease, and Human Brain Evolution; Advance 2009, doi:10.1101/sqb.2009.74.025; Cold Spring Harbor Laboratory Press
^Butler W.T.; Ritchie H. (February 1995). "The nature and functional significance of dentin extracellular matrix proteins.". Int J Dev Biol. 39 (1): 169–79. PMID7626404.