NBPF10

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NBPF20
Identifiers
Aliases NBPF20
External IDs HomoloGene: 41035 GeneCards: NBPF20
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001278267

n/a

RefSeq (protein)

NP_001032764
NP_001264373

n/a

Location (UCSC) Chr 1: 145.29 – 145.41 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Neuroblastoma breakpoint family member 10 is a protein that in Homo sapiens is encoded by the NBPF10 gene.[2][3]

The full gene is 75,313 bp, with the major isoform of mRNA being 10,697 bp long. The gene is located at 1q21.1. NBPF contains what is known as the DUF1220 repeats. The highly conserved, repeated region is believed to be originated from MGC8902. The NBPF family has been linked to primate evolution.[3] It is assumed to be related to the 1q21.1 deletion syndrome and 1q21.1 duplication syndrome.[4]

Homology[edit]

Paralogs of NBPF10 includes other NBPF family members. Orthologs of NBPF10 are found in other primates; distant orthologs are found in bovine, equine, and canine

NBPF10 paralogs and orthologs unrooted phylogenetic tree

Functional role[edit]

Although NBPF10's function is unknown, there is reason to believe that NBPF10 is an important biomarker for the Odontoblast Phenotype[5]

Gene Neighborhood[edit]

NOTCH2NL, SEC22B, HFE2, TXNIP are close neighbors of NBPF10. All of these neighboring genes are well studied in their own right.

NBPF10's chromosomal location

Post-translational modification[edit]

NBPF10 has extremely low threonine content which may make the protein less susceptible to post-translational modification.[citation needed]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Entrez Gene: NBPF10 neuroblastoma breakpoint family, member 10". Retrieved 28 April 2010. 
  3. ^ a b Vandepoele K, Van Roy N, Staes K, Speleman F, van Roy F (November 2005). "A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution". Mol. Biol. Evol. 22 (11): 2265–74. doi:10.1093/molbev/msi222. PMID 16079250. 
  4. ^ e.g.: L. Dumas and J.M. Sikela; DUF1220 Domains, Cognitive Disease, and Human Brain Evolution; Advance 2009, doi:10.1101/sqb.2009.74.025; Cold Spring Harbor Laboratory Press
  5. ^ Butler W.T.; Ritchie H. (February 1995). "The nature and functional significance of dentin extracellular matrix proteins.". Int J Dev Biol. 39 (1): 169–79. PMID 7626404.