Nanoelectromechanical systems mass spectrometer

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A nanoelectromechanical systems mass spectrometer (NEMS MS) is an instrument measuring the mass of analyte particles by detecting the frequency shift caused by the adsorption of the particles on a NEMS resonator.

It was first reported by a group of scientists led by Michael Roukes at the California Institute of Technology in 2004.[1] They developed single molecule analysis in 2009.[2] [3] Single-biomolecule mass measurements were accomplished in 2012.[4] A hybrid NEMS-MS/TOF-MS instrument was reported in 2015.[5]

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  1. ^ Ekinci, K. L.; Huang, X. M. H.; Roukes, M. L. (2004). "Ultrasensitive nanoelectromechanical mass detection". Applied Physics Letters. 84 (22): 4469. arXiv:cond-mat/0402528Freely accessible. Bibcode:2004ApPhL..84.4469E. doi:10.1063/1.1755417. 
  2. ^ Naik, A. K.; Hanay, M. S.; Hiebert, W. K.; Feng, X. L.; Roukes, M. L. (21 June 2009). "Towards single-molecule nanomechanical mass spectrometry". Nature Nanotechnology. 4 (7): 445–450. Bibcode:2009NatNa...4..445N. doi:10.1038/nnano.2009.152. 
  3. ^ US application 2009/0261241, Roukes et al, "Single molecule mass spectroscopy enabled by nanoelectromechanical systems (nems-ms)", published 2009-10-22 
  4. ^ Hanay, M. S.; Kelber, S. K.; Naik, A. K.; Chi, D.; Hentz, S.; Bullard, E.C.; Colinet, E.; Duraffourg, L.; Roukes, M.L. (26 August 2012). "Single-protein nanomechanical mass spectrometry in real time". Nature Nanotechnology. 7 (9): 602–608. Bibcode:2012NatNa...7..602H. doi:10.1038/NNANO.2012.119. 
  5. ^ Sage, Eric; Brenac, Ariel; Alava, Thomas; Morel, Robert; Dupré, Cécilia; Hanay, Mehmet Selim; Roukes, Michael L.; Duraffourg, Laurent; Masselon, Christophe; Hentz, Sébastien (10 March 2015). "Neutral particle mass spectrometry with nanomechanical systems". Nature Communications. 6: 6482. arXiv:1405.7281Freely accessible. Bibcode:2015NatCo...6E6482S. doi:10.1038/ncomms7482. PMC 4366497Freely accessible. PMID 25753929. 

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