Nanoelectromechanical systems mass spectrometer
A nanoelectromechanical systems mass spectrometer (NEMS MS) is an instrument measuring the mass of analyte particles by detecting the frequency shift caused by the adsorption of the particles on a NEMS resonator.
It was first reported by a group of scientists led by Michael Roukes at the California Institute of Technology in 2004.[1] They developed single molecule analysis in 2009.[2] [3] Single-biomolecule mass measurements were accomplished in 2012.[4] A hybrid NEMS-MS/TOF-MS instrument was reported in 2015.[5]
See also
- Nanoelectromechanical systems
- Quartz crystal microbalance
- Quartz crystal microbalance with dissipation monitoring
References
- ^ Ekinci, K. L.; Huang, X. M. H.; Roukes, M. L. (2004). "Ultrasensitive nanoelectromechanical mass detection". Applied Physics Letters. 84 (22): 4469. doi:10.1063/1.1755417.
- ^ Naik, A. K.; Hanay, M. S.; Hiebert, W. K.; Feng, X. L.; Roukes, M. L. (21 June 2009). "Towards single-molecule nanomechanical mass spectrometry". Nature Nanotechnology. 4 (7): 445–450. doi:10.1038/nnano.2009.152.
- ^ US application 2009/0261241, Roukes et al, "Single molecule mass spectroscopy enabled by nanoelectromechanical systems (nems-ms)", published 2009-10-22
- ^ Hanay, M. S.; Kelber, S. K.; Naik, A. K.; Chi, D.; Hentz, S.; Bullard, E.C.; Colinet, E.; Duraffourg, L.; Roukes, M.L. (26 August 2012). "Single-protein nanomechanical mass spectrometry in real time". Nature Nanotechnology. 7 (9): 602–608. doi:10.1038/NNANO.2012.119.
- ^ Sage, Eric; Brenac, Ariel; Alava, Thomas; Morel, Robert; Dupré, Cécilia; Hanay, Mehmet Selim; Roukes, Michael L.; Duraffourg, Laurent; Masselon, Christophe; Hentz, Sébastien (10 March 2015). "Neutral particle mass spectrometry with nanomechanical systems". Nature Communications. 6: 6482. doi:10.1038/ncomms7482.
External links
| Ion source | |
|---|---|
| Mass analyzer | |
| Detector | |
| MS combination | |
| Fragmentation | |
