The route begins with an intersection with State Route 321. SR 322 heads northward through town as Main Street. Upon intersecting U.S. Route 93, the route becomes Eagle Valley Road, heading eastward. SR 322 then turns northward, passing briefly through the town of Ursine before meeting its terminus at Spring Valley State Park.
The route was the second highway in the state to be known as State Route 85, established in the 1970s. This designation was removed in favor of SR 322 in the 1976 renumbering of Nevada's state highways.