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O-phospho-L-serine—tRNA ligase

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O-phospho-L-serine---tRNA ligase
Identifiers
EC no.6.1.1.27
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
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NCBIproteins

O-phospho-L-serine---tRNA ligase (EC 6.1.1.27, O-phosphoseryl-tRNA ligase, non-canonical O-phosphoseryl-tRNA synthetase, SepRS) is an enzyme with systematic name O-phospho-L-serine:tRNACys ligase (AMP-forming).[1][2] This enzyme catalyses the following chemical reaction

ATP + O-phospho-L-serine + tRNACys AMP + diphosphate + O-phospho-L-seryl-tRNACys

In organisms like Archaeoglobus fulgidus, this enzyme ligates O-phosphoserine to tRNACys.

References

  1. ^ Fukunaga, R. and Yokoyama, S. (2007). "Structural insights into the first step of RNA-dependent cysteine biosynthesis in archaea". Nat. Struct. Mol. Biol. 14 (4): 272–279. doi:10.1038/nsmb1219. PMID 17351629.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. ^ Hauenstein, S.I. and Perona, J.J. (2008). "Redundant synthesis of cysteinyl-tRNACys in Methanosarcina mazei". J. Biol. Chem. 283: 22007–22017. doi:10.1074/jbc.M801839200. PMC 2494925. PMID 18559341.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)