O-phospho-L-serine—tRNA ligase
| O-phospho-L-serine---tRNA ligase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 6.1.1.27 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
O-phospho-L-serine---tRNA ligase (EC 6.1.1.27, O-phosphoseryl-tRNA ligase, non-canonical O-phosphoseryl-tRNA synthetase, SepRS) is an enzyme with systematic name O-phospho-L-serine:tRNACys ligase (AMP-forming).[1][2] This enzyme catalyses the following chemical reaction
- ATP + O-phospho-L-serine + tRNACys AMP + diphosphate + O-phospho-L-seryl-tRNACys
In organisms like Archaeoglobus fulgidus, this enzyme ligates O-phosphoserine to tRNACys.
References
- ^ Fukunaga, R. and Yokoyama, S. (2007). "Structural insights into the first step of RNA-dependent cysteine biosynthesis in archaea". Nat. Struct. Mol. Biol. 14 (4): 272–279. doi:10.1038/nsmb1219. PMID 17351629.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Hauenstein, S.I. and Perona, J.J. (2008). "Redundant synthesis of cysteinyl-tRNACys in Methanosarcina mazei". J. Biol. Chem. 283: 22007–22017. doi:10.1074/jbc.M801839200. PMC 2494925. PMID 18559341.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
External links
- O-phospho-L-serine---tRNA+ligase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)