OLR1

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OLR1
Protein OLR1 PDB 1ypo.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases OLR1, CLEC8A, LOX1, LOXIN, SCARE1, SLOX1, oxidized low density lipoprotein receptor 1
External IDs MGI: 1261434 HomoloGene: 1910 GeneCards: OLR1
RNA expression pattern
PBB GE OLR1 210004 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001172632
NM_001172633
NM_002543

NM_001301094
NM_001301096
NM_138648

RefSeq (protein)

NP_001166103
NP_001166104
NP_002534

NP_619589.2
NP_001288023
NP_001288025
NP_619589

Location (UCSC) Chr 12: 10.16 – 10.17 Mb Chr 6: 129.49 – 129.51 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) also known as lectin-type oxidized LDL receptor 1 (LOX-1) is a protein that in humans is encoded by the OLR1 gene.[3][4]

Function[edit]

LOX-1 is a receptor protein which belongs to the C-type lectin superfamily. Its gene is regulated through the cyclic AMP signaling pathway. The protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor.[4]

Clinical significance[edit]

Mutations of the OLR1 gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease.[4] When applied to human macrophage-derived foam cells in vitro, the dietary supplement berberine inhibits the expression of the ORL1 gene in response to oxidized low-density lipoprotein cholesterol,[5] but this has not yet been demonstrated in a living animal or human.

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Li X, Bouzyk MM, Wang X (Nov 1998). "Assignment of the human oxidized low-density lipoprotein receptor gene (OLR1) to chromosome 12p13.1→p12.3, and identification of a polymorphic CA-repeat marker in the OLR1 gene". Cytogenet Cell Genet. 82 (1–2): 34–6. doi:10.1159/000015059. PMID 9763655. 
  4. ^ a b c "Entrez Gene: OLR1 oxidized low density lipoprotein (lectin-like) receptor 1". 
  5. ^ Guan S, Wang B, Li W, Guan J, Fang X (2010). "Effects of berberine on expression of LOX-1 and SR-BI in human macrophage-derived foam cells induced by ox-LDL". Am J Chin Med. 38 (6): 1161–9. doi:10.1142/s0192415x10008548. PMID 21061468. 

Further reading[edit]