Orchestrated objective reduction
Orchestrated objective reduction (Orch-OR) is a model of consciousness theorized by theoretical physicist Sir Roger Penrose and anesthesiologist Stuart Hameroff, which claims that consciousness derives from deeper level, finer scale quantum activities inside the cells, most prevalent in the brain's neurons. It combines approaches from the radically different angles of molecular biology, neuroscience, quantum physics, pharmacology, philosophy, quantum information theory, and aspects of quantum gravity.
While mainstream theories assume that consciousness emerges as the complexity of the computations performed by cerebral neurons increases, Orch-OR posits that consciousness is based on non-computable quantum processing performed by qubits formed collectively on the microtubules of the cells, a process significantly amplified in the neurons. The qubits are based on oscillating dipoles forming superposed resonance rings in helical pathways throughout microtubule lattices. The oscillations are either electric, due to charge separation from London forces, or (most favorably) magnetic, due to electron spin — and possibly also due to nuclear spins (which can remain isolated for longer periods of time), and which occur in gigahertz, megahertz and kilohertz frequency ranges. The orchestration refers to the hypothetical process by which connective proteins, such as microtubule-associated proteins (MAPs), influence or orchestrate the state reduction of the qubits by modifying the spacetime-separation of their superimposed states. The latter is based on Penrose's objective collapse theory for interpreting quantum mechanics, which postulates the existence of an objective threshold governing the collapse of quantum-states, related to the difference of the space-time curvature of these states in the fine scale structure of the universe.
The basis of Orch-OR has been harshly criticized from its inception by mathematicians, philosophers, and scientists, prompting the authors to revise and elaborate many of the peripheral assumptions of the theory, but the core ideas have remained the same. The criticism so far has been concentrated on three issues: Penrose's interpretation of Gödel's theorem which postulates that consciousness is non-computable; Penrose's abductive reasoning linking non-computability to quantum processes; unsuitability of the brain to host the seemingly delicate quantum phenomena required by the theory, since it is considered too "warm, wet and noisy" to avoid decoherence.
- 1 The Penrose–Lucas argument
- 2 Objective reduction
- 3 The creation of the Orch-OR model
- 4 Criticism
- 5 See also
- 6 References
- 7 External links
The Penrose–Lucas argument
In 1931, mathematician and logician Kurt Gödel proved that any effectively generated theory capable of proving basic arithmetic cannot be both consistent and complete. Furthermore, he showed that any such theory also including a statement of its own consistency is inconsistent. A key element of the proof is the use of Gödel numbering to construct a "Gödel sentence" for the theory, which encodes a statement of its own incompleteness, e.g. "This theory can't assert the truth of this statement." This statement is either true but unprovable (incompleteness) or false and provable (inconsistency). An analogous statement has been used to show that humans are subject to the same limits as machines.
However, in his first book on consciousness, The Emperor's New Mind (1989), Penrose made Gödel's theorem the basis of what quickly became an intensely controversial claim. He argued that while a formal proof system cannot prove its own consistency, Gödel-unprovable results are provable by human mathematicians. He takes this disparity to mean that human mathematicians are not describable as formal proof systems, and are therefore running a non-computable algorithm. Similar claims about the implications of Gödel's theorem were originally espoused by the philosopher John Lucas of Merton College, Oxford.
The inescapable conclusion seems to be: Mathematicians are not using a knowably sound calculation procedure in order to ascertain mathematical truth. We deduce that mathematical understanding – the means whereby mathematicians arrive at their conclusions with respect to mathematical truth – cannot be reduced to blind calculation!—Roger Penrose
If correct, the Penrose–Lucas argument creates a need to understand the physical basis of non-computational behaviour in the brain. Most physical laws are computable, and thus algorithmic. However, Penrose determined that wave function collapse was a prime candidate for a non-computable process.
In quantum mechanics, particles are treated differently from the macroscopic objects of classical mechanics. Particles are described not by position vectors, but by wave functions, which evolve according to the Schrödinger equation. Non-stationary wave functions are linear combinations of the eigenstates of the system, a phenomenon described by the superposition principle. When a quantum system interacts with a classical system—i.e. when an observable is measured—the system appears to collapse to a random eigenstate of that observable from a classical vantage point.
If collapse is truly random, then there is no process or algorithm that can deterministically predict its outcome. This provided Penrose with a candidate for the physical basis of the non-computable process that he hypothesized to exist in the brain. However, he disliked the random nature of environmentally-induced collapse, as randomness was not a promising basis for mathematical understanding. Penrose proposed that isolated systems may still undergo a new form of wave function collapse, which he calls objective reduction (OR).
Penrose sought to reconcile general relativity and quantum theory using his own ideas about the possible structure of spacetime. He suggested that at the Planck scale curved spacetime is not continuous, but discrete. Penrose postulates that each separated quantum superposition has its own piece of spacetime curvature, a blister in spacetime. Penrose suggests that gravity exerts a force on these spacetime blisters, which become unstable above the Planck scale of and collapse to just one of the possible states of the particle. The rough threshold for OR is given by Penrose's indeterminacy principle:
- is the time until OR occurs,
- is the gravitational self-energy or the degree of spacetime separation given by the superpositioned mass, and
- is the reduced Planck constant.
Thus, the greater the mass-energy of the object, the faster it will undergo OR, and vice versa. Atomic-level superpositions would require 10 million years to reach OR threshold, while an isolated 1 kilogram object would reach OR threshold in only 10−37s. However objects somewhere between these two scales could collapse on a timescale relevant to neural processing.
An essential feature of Penrose's theory is that the choice of states when objective reduction occurs is selected neither randomly, as are choices following wave function collapse, nor completely algorithmically. Rather, states are selected by a "non-computable" influence embedded in the Planck scale of spacetime geometry. Penrose claims that such information is Platonic, representing pure mathematical truth, aesthetic, and ethical values at the Planck scale. This relates to Penrose's ideas concerning the three worlds: physical, mental, and the Platonic mathematical world. In his theory, the Platonic world corresponds to the geometry of fundamental spacetime that is claimed to support non-computational thinking.
In August 2013, Penrose and Hameroff reported that the experiments have been carried out by Bandyopadhyay et al., supporting Penrose's theory on six out of the twenty theses he puts forward and invalidating none of the others. They subsequently responded to further critiques from a number of sources, including a 2013 critique from an Australian group led by Reimers.
The creation of the Orch-OR model
Penrose and Hameroff initially developed their ideas quite separately from one another, and it was only in the 1990s that they cooperated to produce the Orch-OR theory. Penrose came to the problem from the view point of mathematics and in particular Gödel's theorem, while Hameroff approached it from a career in cancer research and anesthesia that had given him an interest in brain structures. Specifically, when Penrose wrote his first consciousness book, The Emperor's New Mind in 1989, he lacked a detailed proposal for how such quantum processes could be implemented in the brain. Subsequently, Hameroff read The Emperor's New Mind and suggested to Penrose that certain structures within brain cells (neurons) were suitable candidate sites for quantum processing and ultimately for consciousness. The Orch-OR theory arose from the cooperation of these two scientists, and was developed in Penrose's second consciousness book Shadows of the Mind (1994).
Hameroff's contribution to the theory derived from studying brain cells. His interest centered on the cytoskeleton, which provides an internal supportive structure for neurons, and particularly on the microtubules, which are the most important component of the cytoskeleton. As neuroscience has progressed, the role of the cytoskeleton and microtubules has assumed greater importance. In addition to providing structural support, microtubule functions include axoplasmic transport and control of the cell's movement, growth and shape.
Hameroff proposed that microtubules were suitable candidates for quantum processing. Microtubules are made up of tubulin protein subunits. The tubulin protein dimers of the microtubules have hydrophobic pockets which might contain delocalized π electrons. Tubulin has other smaller non-polar regions, for example 8 tryptophans per tubulin, which contain π electron-rich indole rings distributed throughout tubulin with separations of roughly 2 nm. Hameroff claims that this is close enough for the tubulin π electrons to become quantum entangled. During entanglement, particles' states become inseparably correlated.
Hameroff originally suggested the tubulin-subunit electrons would form a Bose–Einstein condensate, but this was discredited. He then proposed a Frohlich condensate, a hypothetical coherent oscillation of dipolar molecules. However, this too has been criticized by Reimers et al. Hameroff then responded to Reimers. "Reimers et al have most definitely NOT shown that strong or coherent Frohlich condensation in microtubules is unfeasible. The model microtubule on which they base their Hamiltonian is not a microtubule structure, but a simple linear chain of oscillators." Hameroff reasoned that such condensate behavior would magnify nanoscopic quantum effects to have large scale influences in the brain.
Hameroff proposed that condensates in microtubules in one neuron can link with microtubule condensates in other neurons and glial cells via the gap junctions of electrical synapses. Hameroff proposed that the gap between the cells is sufficiently small that quantum objects can tunnel across it, allowing them to extend across a large area of the brain. He further postulated that the action of this large-scale quantum activity is the source of 40 Hz gamma waves. Here, Hameroff built upon the much less controversial theory that gap junctions are related to the gamma oscillation.
The Orch-OR theory combines the Penrose–Lucas argument with Hameroff's hypothesis on quantum processing in microtubules. Altogether, it proposes that when condensates in the brain undergo an objective reduction of their wave function, their collapse connects non-computational decision making to experiences embedded in the fundamental geometry of spacetime.
The theory further proposes that the microtubules both influence and are influenced by the conventional activity at the synapses between neurons.
Further to this, Hameroff in 1998 made 8 probable assumptions and 20 testable predictions to back his proposal. However, many of these proposals have been disproven (see "Criticism" section, below).
In January 2014 Hameroff and Penrose announced that the discovery of quantum vibrations in microtubules by Anirban Bandyopadhyay of the National Institute for Materials Science in Japan confirms the hypothesis of Orch-OR theory.
Criticism of the Penrose–Lucas argument
The Penrose–Lucas argument about the implications of Gödel's incompleteness theorem for computational theories of human intelligence has been widely criticized by mathematicians, computer scientists, and philosophers, and the consensus among experts in these fields is that the argument fails, with different authors choosing different aspects of the argument to attack.
Geoffery LaForte points out that in order to know the truth of an unprovable Gödel sentence, one must already know the formal system is consistent. Referencing Benacerraf, he then demonstrates that humans cannot prove that they are consistent, and in all likelihood human brains are inconsistent. He points to contradictions from within Penrose's own writings as evidence. Similarly, Marvin Minsky argues that because humans can construe false ideas to be factual, human mathematical understanding need not be consistent, and consciousness may easily have a deterministic basis.
Solomon Feferman, a professor of mathematics, logic and philosophy has made criticisms of Penrose's argument. He faults detailed points in Penrose's second book, Shadows of the Mind. As a mathematician, he[clarification needed] argues that mathematicians do not progress by computer-like or mechanistic search through proofs, but by trial-and-error reasoning, insight and inspiration, and that machines cannot share this approach with humans. However, he thinks that Penrose goes too far in his arguments. Feferman points out that everyday mathematics, as used in science, can in practice be formalized. He also rejects Penrose's Platonism.
John Searle criticizes Penrose's appeal to Gödel as resting on the fallacy that all computational algorithms must be capable of mathematical description. As a counter-example, Searle cites the assignment of license plate numbers to specific vehicle identification numbers, in order to register a vehicle. According to Searle, no mathematical function can be used to connect a known VIN with its LPN, but the process of assignment is quite simple—namely, "first come, first served"—and can be performed entirely by a computer. However, as an algorithm (as defined in the Oxford American Dictionary) is a 'set of rules to be followed in calculations or problem-solving operations', the assignment of LPN to a VIN is not an algorithm as such, merely use of a database in which every VPN has a corresponding LPN. No algorithm could arbitrarily 'compute' database assignments. Thus, Searle's counter-example does not describe a computational algorithm that is not mathematically describable.
Decoherence in living organisms
A fundamental objection to the Orch OR hypothesis was put forward in 2000 by Max Tegmark who claimed that any quantum coherent system in the brain would undergo wave function collapse due to environmental interaction long before it could ever influence neural processes (the "warm, wet and noisy" argument, as it was later came to be known). Max Tegmark determined the decoherence timescale of microtubule entanglement at brain temperatures to be extremely rapid, in the scale of a femtoseconds, far too brief to be relevant to neural processing. There were scientists that sided with Tegmark's analysis, insisting that quantum coherence does not play, or does not need to play any major role in neurophysiology.[irrelevant citation]
In response to Tegmark's claims, physicists Scott Hagan, Jack Tuszynski and Hameroff claimed that Tegmark did not address the Orch-OR model, but instead a model of his own construction. This involved superpositions of quanta separated by 24 nm rather than the much smaller separations stipulated for Orch-OR. As a result, Hameroff's group claimed a decoherence time seven orders of magnitude greater than Tegmark's, although still far below 25 ms. Also, Hameroff's group suggested that the Debye layer of counterions could screen thermal fluctuations, and that the surrounding actin gel might enhance the ordering of water, further screening noise. Also, they suggest incoherent metabolic energy could further order water, and finally that the configuration of the microtubule lattice might be suitable for quantum error correction, a means of resisting quantum decoherence.
Since the 90's numerous counter-observations to the "warm, wet and noisy" argument have been found to exist at normal temperatures, in-vitro, or inside living organism (i.e. photosynthesis, bird navigation). For example, Harvard researchers have been able to achieve quantum states lasting for 2 sec at room temperatures using pure diamonds. In the past 6 years, evidence has accumulated that plants routinely use quantum coherent electron transport at ambient temperatures in photosynthesis. More recently(2014), a team in University of Arizona based on theoretical quantum biophysics and computer simulations analyzed quantum coherence among tryptophan π resonance rings in tubulin, the component protein in microtubules, and claimed that quantum dipole coupling among tryptophan π resonance clouds, mediated by exciton hopping or Forster resonance energy transfer (FRET) across the tubulin protein are plausible.
In 2009, the debate focused around papers by Reimers et al. and McKemmish et al. Earlier versions of the theory had required tubulin-electrons to form either Bose–Einsteins or Frohlich condensates, and the Reimers group claimed that these they were experimentally unfounded. Additionally they claimed that microtubules could only support 'weak' 8 MHz coherence. The first argument were made void by later revisions of the theory that described dipole oscillations due to London forces and possibly due to magnetic and/or nuclear spin cloud formations. On the second issue the theory has been retrofitted so that 8 MHz coherence is sufficient to support the whole Orch-OR hypothesis.
McKemmish et al. made two claims; firstly that aromatic molecules cannot switch states because they are delocalised, and secondly that changes in tubulin protein-conformation driven by GTP conversion would result in a prohibitive energy requirement. Hameroff & Penrose on the first issue responded that they were referring to the behaviour of two or more electron clouds, inherently non-localised. For the second argument they responded that no GTP conversion is needed since in the latest version of the theory the conformation-switching is not necessary, and has been replaced by oscillation due to the London forces produced by the electron cloud dipole states.
Neuron Cell biology
Hameroff proposed that microtubule coherence reaches the synapses via dendritic lamellar bodies (DLBs), where it could influence synaptic firing and be transmitted across the synaptic cleft to other neurons. However De Zeeuw et al. proved this impossible, by showing that DLBs are located micrometers away from gap junctions. Anirban Bandyopadhyay and his team speculate that this issue might be resolved if their notion of wireless transmission of information globally across the entire brain is proven, yet Hameroff and Penrose doubt whether such a wireless transmission would be capable of transmitting superimposed quantum-states.
Hameroff's 1998 hypothesis required that cortical dendrites contain primarily 'A' lattice microtubules, but this was already experimentally disproved in 1994 by Kikkawa et al who showed that all in vivo microtubules have a 'B' lattice and a seam. However, the recent research by Anirban Bandyopadhyay showed that microtubules can change their structure from B-lattice to A-lattice as part of the processing of information, and tubulin in microtubules exists in multiple states.[irrelevant citation]
Hameroff also speculated that visual photons instead of decohering in the retina are detected directly by the cones and rods, and subsequently connect with the retinal glia cells via gap junctions, but this was falsified.
Several other criticisms regarding biology have come to the fore over the years. Papers by Georgiev, D. point to a number of problems with Hameroff's proposals, including a lack of explanation for the probabilistic firing of axonal synapses, an error in the calculated number of the tubulin dimers per cortical neuron. Nevertheless, Hameroff insisted in a 2013 interview that those falsifications are invalid, including the assertions made by this Wikipedia article.
- Electromagnetic theories of consciousness
- Holonomic brain theory
- Many-minds interpretation
- Penrose interpretation
- Quantum Aspects of Life (book)
- Quantum mind
- Hameroff, Stuart; Penrose, Roger (March 2014). "Reply to criticism of the ‘Orch OR qubit’ – ‘Orchestrated objective reduction’ is scientifically justified". Physics of Life Reviews (Elsevier) 11 (1): 94–100. doi:10.1016/j.plrev.2013.11.013. Retrieved 17 March 2014.
- McCulloch, Warren; Pitts, Walter (12 January 1943). "A logical calculus of the ideas immanent in nervous activity". The bulletin of mathematical biophysics (Kluwer Academic Publishers) 5 (4): 115–133. doi:10.1007/BF02478259. Retrieved 17 March 2014.
- HODGKIN; HUXLEY (1952). "A quantitative description of membrane current and its application to conduction and excitation in nerve." (PDF). The Journal of Physiology (MEDLINE) 117 (4): 500–544. Retrieved 17 March 2014.
- Chopra, Deepak (2014-03-18). "'Collision Course' in the Science of Consciousness: Grand Theories to Clash at Tucson Conference". The Huffington Post (United States: TheHuffingtonPost.com, Inc). Archived from the original on 18 March 2014. Retrieved 2014-03-18.
- Hameroff, Stuart; Penrose, Roger (March 2014). "Reply to seven commentaries on "Consciousness in the universe: Review of the ‘Orch OR’ theory"". Physics of Life Reviews (Elsevier) 11 (1): 104–112. doi:10.1016/j.plrev.2013.11.014. Retrieved 16 March 2014.
- Hameroff, Stuart; Penrose, Roger (March 2014). "Consciousness in the universe: A review of the ‘Orch OR’ theory". Physics of Life Reviews (Elsevier) 11 (1): 39–78. doi:10.1016/j.plrev.2013.08.002. PMID 24070914. Retrieved 16 March 2014.
- Natalie Wolchover (31 October 2013). "Physicists Eye Quantum-Gravity Interface". Quanta Magazine (Article). Simons Foundation. Retrieved 19 March 2014.
- LaForte, Geoffrey, Patrick J. Hayes, and Kenneth M. Ford 1998.Why Gödel's Theorem Cannot Refute Computationalism. Artificial Intelligence, 104:265–286.
- Feferman, Solomon (1996). "Penrose's Gödelian argument". PSYCHE 2: 21–32. CiteSeerX: 10
.1 .1 .130 .7027.
- Krajewski, Stanislaw 2007. On Gödel's Theorem and Mechanism: Inconsistency or Unsoundness is Unavoidable in any Attempt to 'Out-Gödel' the Mechanist. Fundamenta Informaticae 81, 173–181. Reprinted in in Logic, Philosophy and Foundations of Mathematics and Computer Science:In Recognition of Professor Andrzej Grzegorczyk (2008), p. 173
- "MindPapers: 6.1b. Godelian arguments". Consc.net. Retrieved 2014-07-28.
- "References for Criticisms of the Gödelian Argument". Users.ox.ac.uk. 1999-07-10. Retrieved 2014-07-28.
- Boolos, George, et al. 1990. An Open Peer Commentary on The Emperor's New Mind. Behavioral and Brain Sciences 13 (4) 655.
- Davis, Martin 1993. How subtle is Gödel's theorem? More on Roger Penrose. Behavioral and Brain Sciences, 16, 611–612. Online version at Davis' faculty page at http://cs.nyu.edu/cs/faculty/davism/
- Lewis, David K. 1969.Lucas against mechanism. Philosophy 44 231–233.
- Putnam, Hilary 1995. Review of Shadows of the Mind. In Bulletin of the American Mathematical Society 32, 370–373 (also see Putnam's less technical criticisms in his New York Times review)
- Tegmark, Max (April 2000). "Importance of quantum decoherence in brain processes". Phys. Rev. E 61 (4): 4194. Bibcode:2000PhRvE..61.4194T. doi:10.1103/PhysRevE.61.4194. Retrieved 18 November 2012.
- McKemmish, L.K., Reimers, J.R., McKenzie, R.H., Mark, A.E., and Hush, N.S. (2009). "Penrose–Hameroff orchestrated objective-reduction proposal for human consciousness is not biologically feasible". Physical Review E 80 (2): 021912–021916. Bibcode:2009PhRvE..80b1912M. doi:10.1103/PhysRevE.80.021912.
- Georgiev, D.D. (2007). "Falsifications of Hameroff–Penrose Orch OR model of consciousness and novel avenues for development of quantum mind theory". NeuroQuantology 5 (1): 145–174. doi:10.14704/nq.2007.5.1.121.
- Koch, Christof; Hepp, Klaus (30 March 2006). "Quantum mechanics in the brain". Nature 440 (7084): 611. doi:10.1038/440611a. Retrieved 8 August 2013.
- Hepp, K. (27 September 2012). "Coherence and decoherence in the brain". J. Math. Phys. 53 (9): 095222. doi:10.1063/1.4752474. Retrieved 8 August 2013.
- "Discovery of Quantum Vibrations in "Microtubules" Inside Brain Neurons Corroborates Controversial 20-Year-Old Theory of Consciousness". elsevier.com (press release). Amsterdam: Elsevier. 16 January 2014. Retrieved 19 March 2014.
- Penrose, Roger (1989). The Emperor's New Mind: Concerning Computers, Minds and The Laws of Physics. Oxford University Press. p. 480. ISBN 0-19-851973-7.
- Hofstadter 1979, pp. 476–477, Russell & Norvig 2003, p. 950, Turing 1950 under "The Argument from Mathematics" where he writes "although it is established that there are limitations to the powers of any particular machine, it has only been stated, without sort of proof, that no such limitations apply to the human intellect."
- Roger Penrose. Mathematical intelligence. In Jean Khalfa, editor, What is Intelligence?, chapter 5, pages 107–136. Cambridge University Press, Cambridge, United Kingdom, 1994.
- Penrose, Roger (1989). Shadows of the Mind: A Search for the Missing Science of Consciousness. Oxford University Press. p. 457. ISBN 0-19-853978-9.
- Marshall, W., Simon, C., Penrose, R., and Bouwmeester, D. (2003). "Towards quantum superpositions of a mirror". Physical Review Letters 91 (13): 130401. arXiv:quant-ph/0210001. Bibcode:2003PhRvL..91m0401M. doi:10.1103/PhysRevLett.91.130401. PMID 14525288.
- "Discovery of quantum vibrations in microtubules inside brain neurons corroborates controversial 20-year-old theory of consciousness". KurzweilAI. 2014-01-16. Retrieved 2014-02-01.
- "Penrose, Hameroff & Bandyopadhyay, Lecture: Microtubules and the great debate about consciousness (Lezing: Microtubuli & het grote debat over het bewustzijn)". Brakke Grond. 2014-01-16. Retrieved 2014-02-01.
- Hameroff, S.R., and Watt, R.C. (1982). "Information processing in microtubules" (PDF). Journal of Theoretical Biology 98 (4): 549–561. doi:10.1016/0022-5193(82)90137-0. PMID 6185798.
- Hameroff, S.R. (1987). Ultimate Computing. Elsevier. ISBN 0-444-70283-0.
- Hameroff, Stuart (2008). "That's life! The geometry of π electron resonance clouds". In Abbott, D; Davies, P; Pati, A. Quantum aspects of life (PDF). World Scientific. pp. 403–434. Retrieved Jan 21, 2010.
- Roger Penrose & Stuart Hameroff (2011). "Consciousness in the Universe: Neuroscience, Quantum Space-Time Geometry and Orch OR Theory". Journal of Cosmology 14.
- Reimers, Jeffrey R.; McKemmish, Laura K.; McKenzie, Ross H.; Mark, Alan E.; Hush, Noel S. (17 March 2009). "Weak, strong, and coherent regimes of Fröhlich condensation and their applications to terahertz medicine and quantum consciousness". PNAS 106 (11): 4219–4224. Bibcode:2009PNAS..106.4219R. doi:10.1073/pnas.0806273106. PMC 2657444. PMID 19251667.
- Hameroff, S.R. (2006). "The entwined mysteries of anesthesia and consciousness". Anesthesiology 105 (2): 400–412. doi:10.1097/00000542-200608000-00024. PMID 16871075.
- Hameroff, S. (2009). "The "conscious pilot"—dendritic synchrony moves through the brain to mediate consciousness". Journal of Biological Physics 36 (1): 71–93. doi:10.1007/s10867-009-9148-x. PMC 2791805. PMID 19669425.
- Bennett, M.V.L., and Zukin, R.S. (2004). "Electrical Coupling and Neuronal Synchronization in the Mammalian Brain". Neuron 41 (4): 495–511. doi:10.1016/S0896-6273(04)00043-1. PMID 14980200.
- Hameroff, S.R. (1998). "Quantum Computation In Brain Microtubules? The Penrose–Hameroff "Orch OR" model of consciousness". Philosophical Transactions of the Royal Society A 356: 1869–1896. doi:10.1098/rsta.1998.0254.
- Anirban Bandyopadhyay (26 March 2013). "Multi-level memory-switching properties of a single brain microtubule". Applied Physics Letter (American Institute of Physics) 102 (12). doi:10.1063/1.4793995. Retrieved 16 March 2014.
- Anirban Bandyopadhyay (15 March 2013). "Atomic water channel controlling remarkable properties of a single brain microtubule: correlating single protein to its supramolecular assembly". Biosens Bioelectron (Elsevier) 102 (12): 141–8. doi:10.1016/j.bios.2013.02.050. PMID 23567633. Retrieved 16 March 2014.
- "Discovery of quantum vibrations in 'microtubules' inside brain neurons supports controversial theory of consciousness". ScienceDaily. Jan 2014. Retrieved 2014-02-22.
- Bringsjord, S. and Xiao, H. 2000. A Refutation of Penrose's Gödelian Case Against Artificial Intelligence. Journal of Experimental and Theoretical Artificial Intelligence 12: 307–329. The authors write that it is "generally agreed" that Penrose "failed to destroy the computational conception of mind."
- In an article at http://www.mth.kcl.ac.uk/~llandau/Homepage/Math/penrose.html L.J. Landau at the Mathematics Department of King's College London writes that "Penrose's argument, its basis and implications, is rejected by experts in the fields which it touches."
- Princeton Philosophy professor John Burgess writes in On the Outside Looking In: A Caution about Conservativeness (published in Kurt Gödel: Essays for his Centennial, with the following comments found on pp. 131–132) that "the consensus view of logicians today seems to be that the Lucas–Penrose argument is fallacious, though as I have said elsewhere, there is at least this much to be said for Lucas and Penrose, that logicians are not unanimously agreed as to where precisely the fallacy in their argument lies. There are at least three points at which the argument may be attacked."
- Dershowitz, Nachum 2005. The Four Sons of Penrose, in Proceedings of the Eleventh Conference on Logic for Programming, Artificial Intelligence, and Reasoning (LPAR; Jamaica), G. Sutcliffe and A. Voronkov, eds., Lecture Notes in Computer Science, vol. 3835, Springer-Verlag, Berlin, pp. 125–138.
- Marvin Minsky. "Conscious Machines." Machinery of Consciousness, Proceedings, National Research Council of Canada, 75th Anniversary Symposium on Science in Society, June 1991.
- Feferman, S. (1996). "Penrose's Gödelian argument" (PDF). Psyche 2: 21–32.
- Searle, John R. The Mystery of Consciousness. 1997. ISBN 0-940322-06-4. pp 85–86.
- Hagan, S., Hameroff, S., and Tuszyński, J. (2002). "Quantum Computation in Brain Microtubules? Decoherence and Biological Feasibility". Physical Review E 65 (6): 061901. arXiv:quant-ph/0005025. Bibcode:2002PhRvE..65f1901H. doi:10.1103/PhysRevE.65.061901. Retrieved 16 March 2014.
- Hameroff, S. (2006). "Consciousness, Neurobiology and Quantum Mechanics". In Tuszynski, Jack. The Emerging Physics of Consciousness. Springer. pp. 193–253.
- Baron, David. "Quantum computing, no cooling required | Harvard Gazette". News.harvard.edu. Retrieved 2014-07-28.
- Engel, G.S., Calhoun, T.R., Read, E.L., Ahn, T.-K., Mancal, T., Cheng, Y.-C., Blankenship, R.E., and Fleming, G.R. (2007). "Evidence for wavelike energy transfer through quantum coherence in photosynthetic systems". Nature 446 (7137): 782–786. Bibcode:2007Natur.446..782E. doi:10.1038/nature05678. PMID 17429397. Retrieved 17 March 2014.
- Craddock, Travis John Adrian; Friesen, Douglas; Mane, Jonathan; Hameroff, Stuart; Tuszynski, Jack (17 Sep 2014). "The feasibility of coherent energy transfer in microtubules". Journal of the Royal Society – Interface 11 (100): 1742–5662. doi:10.1098/rsif.2014.0677. Retrieved 24 Sep 2014.
- Reimers, Jeffrey; McKemmish, Laura; McKenziec, Ross; Markd, Alan; Hush, Noel. "The revised Penrose-Hameroff orchestrated objective-reduction proposal for human consciousness is not scientifically justified: Comment on "Consciousness in the universe: A review of the 'Orch OR' theory" by Hameroff and Penrose." (PDF). Physics of Life reviews 11 (2014): 101–103. doi:10.1016/j.plrev.2013.11.003. Retrieved 24 Sep 2014.
- Georgiev, D.D. (2009). "Remarks on the number of tubulin dimers per neuron and implications for Hameroff–Penrose Orch". NeuroQuantology 7 (4): 677–679. doi:10.1038/npre.2009.3860.1.
- De Zeeuw, C.I., Hertzberg, E.L., Mugnaini, E. (1995). "The dendritic lamellar body: A new neuronal organelle putatively associated with dendrodentritic gap junctions". Journal of Neuroscience 15 (2): 1587–1604. PMID 7869120.
- Subrata Ghosh, Satyajit Sahu, Anirban Bandyopadhyaya (2013). "Evidence of massive global synchronization and the consciousness: Comment on "Consciousness in the universe: A review of the ‘Orch OR’ theory" by Hameroff and Penrose". Physics of Life Reviews. doi:10.1016/j.plrev.2013.10.007.
- Kikkawa, M., Ishikawa, T., Nakata, T., Wakabayashi, T., Hirokawa, N. (1994). "Direct visualization of the microtubule lattice seam both in vitro and in vivo". Journal of Cell Biology 127 (6): 1965–1971. doi:10.1083/jcb.127.6.1965. PMC 2120284. PMID 7806574.
- Kikkawa, M., Metlagel, Z. (2006). "A molecular "zipper" for microtubules". Cell 127 (7): 1302–1304. doi:10.1016/j.cell.2006.12.009. PMID 17190594.
- F. J. Binmöller & C. M. Müller (1992). "Postnatal development of dye-coupling among astrocytes in rat visual cortex". Glia 6 (2): 127–137. doi:10.1002/glia.440060207. PMID 1328051.
- Georgiev, D. (2011). "Photons do collapse in the retina not in the brain cortex: Evidence from visual illusions". Neuroquantology 9 (2): 206–231. arXiv:quant-ph/0208053. Bibcode:2002quant.ph..8053G. doi:10.14704/nq.2011.9.2.403.
- Danaylov, Nikola, ed. (12 Sep 2013). Stuart Hameroff on Singularity 1 on 1: Consciousness is More than Computation!. Singularity Weblog. Event occurs at 00:30:59. Retrieved 25 March 2014.
They [the wikipedia article] talk about [...] some fairly minor things, all of which are wrong! [...] I dispute Wikipedia :-)