Oxalate—CoA ligase
Appearance
oxalate-CoA ligase | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
EC no. | 6.2.1.8 | ||||||||
CAS no. | 37318-57-3 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
|
In enzymology, an oxalate-CoA ligase (EC 6.2.1.8) is an enzyme that catalyzes the chemical reaction
- ATP + oxalate + CoA AMP + diphosphate + oxalyl-CoA
The 3 substrates of this enzyme are ATP, oxalate, and coenzyme A (CoA), whereas its 3 products are AMP, diphosphate, and oxalyl-CoA.
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is oxalate:CoA ligase (AMP-forming). Other names in common use include oxalyl-CoA synthetase, and oxalyl coenzyme A synthetase. This enzyme participates in glyoxylate and dicarboxylate metabolism.
Organisms with Oxalate-CoA Ligases include:
Arabidopsis thaliana[1]
Saccharomyces cerevisiae [2]
References
- Giovanelli J (1966). "Oxalyl-coenzyme A synthetase from pea seeds". Biochim. Biophys. Acta. 118 (1): 124–43. doi:10.1016/s0926-6593(66)80151-0. PMID 4288975.