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P21 protein (Cdc42/Rac)-activated kinase 4
Protein PAK4 PDB 2bva.png
PDB rendering based on 2bva.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbol PAK4
External IDs OMIM605451 MGI1917834 HomoloGene4300 ChEMBL: 4482 GeneCards: PAK4 Gene
EC number
RNA expression pattern
PBB GE PAK4 33814 at tn.png
PBB GE PAK4 203154 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10298 70584
Ensembl ENSG00000130669 ENSMUSG00000030602
UniProt O96013 Q8BTW9
RefSeq (mRNA) NM_001014831 NM_027470
RefSeq (protein) NP_001014831 NP_081746
Location (UCSC) Chr 19:
39.13 – 39.18 Mb
Chr 7:
28.4 – 28.6 Mb
PubMed search [1] [2]

Serine/threonine-protein kinase PAK 4 is an enzyme that in humans is encoded by the PAK4 gene.[1][2][3]

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[3] PAK4 has been shown to be repressed at translational level by miR-24.[4]


PAK4 has been shown to interact with CDC42,[1][5][6] Integrin, beta 5[7] and LIMK1.[8]


  1. ^ a b Abo A, Qu J, Cammarano MS, Dan C, Fritsch A, Baud V, Belisle B, Minden A (Jan 1999). "PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia". EMBO J 17 (22): 6527–40. doi:10.1093/emboj/17.22.6527. PMC 1171000. PMID 9822598. 
  2. ^ Bagrodia S, Cerione RA (Oct 1999). "Pak to the future". Trends Cell Biol 9 (9): 350–5. doi:10.1016/S0962-8924(99)01618-9. PMID 10461188. 
  3. ^ a b "Entrez Gene: PAK4 p21(CDKN1A)-activated kinase 4". 
  4. ^ Amelio I, Lena AM, Viticchiè G, Shalom-Feuerstein R, Terrinoni A, Dinsdale D, Russo G, Fortunato C, Bonanno E, Spagnoli LG, Aberdam D, Knight RA, Candi E, Melino G. (October 2012). "miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration". The Journal of Cell Biology 199 (2): 347–63. doi:10.1083/jcb.201203134. PMID 23071155. 
  5. ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  6. ^ Dan, Chuntao; Nath Niharika; Liberto Muriel; Minden Audrey (Jan 2002). "PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells". Mol. Cell. Biol. (United States) 22 (2): 567–77. doi:10.1128/MCB.22.2.567-577.2002. ISSN 0270-7306. PMC 139731. PMID 11756552. 
  7. ^ Zhang, Hongquan; Li Zhilun; Viklund Eva-Karin; Strömblad Staffan (Sep 2002). "P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration". J. Cell Biol. (United States) 158 (7): 1287–97. doi:10.1083/jcb.200207008. ISSN 0021-9525. PMC 2173231. PMID 12356872. 
  8. ^ Dan, C; Kelly A; Bernard O; Minden A (Aug 2001). "Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin". J. Biol. Chem. (United States) 276 (34): 32115–21. doi:10.1074/jbc.M100871200. ISSN 0021-9258. PMID 11413130. 

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