PIGH

PIGH
Identifiers
Aliases	PIGH, GPI-H, phosphatidylinositol glycan anchor biosynthesis class H
External IDs	OMIM: 600154; MGI: 99463; HomoloGene: 3361; GeneCards: PIGH; OMA:PIGH - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	67,600,286 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	79,136,425 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; left lobe of thyroid gland; ; right adrenal gland; ; left adrenal gland; ; right lobe of thyroid gland; ; minor salivary glands; ; skin of abdomen; ; cerebellar hemisphere; ; gastric mucosa; ; gastrocnemius muscle;
	Top expressed in
	Paneth cell; ; seminal vesicula; ; conjunctival fornix; ; condyle; ; fossa; ; renal corpuscle; ; medullary collecting duct; ; external carotid artery; ; internal carotid artery; ; retinal pigment epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; phosphatidylinositol N-acetylglucosaminyltransferase activity; catalytic activity; glycosyltransferase activity;
Cellular component	cytoplasm; endoplasmic reticulum membrane; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex; endoplasmic reticulum; membrane; integral component of membrane;
Biological process	GPI anchor biosynthetic process; preassembly of GPI anchor in ER membrane; metabolism;
	Sources:Amigo / QuickGO
Orthologs
	5283
	110417
	ENSG00000100564
	ENSMUSG00000021120
	Q14442
	Q5M9N4
	NM_004569; NM_001363694
	NM_029988
	NP_004560; NP_001350623
	NP_084264
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatidylinositol N-acetylglucosaminyltransferase subunit H is an enzyme that in humans is encoded by the PIGH gene.^[5]^[6] The PIGH gene is located on the reverse strand of chromosome 14 in humans, and is neighbored by TMEM229B.^[7]

Template:PBB Summary

Interactions

PIGH has been shown to interact with PIGQ.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100564 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021120 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ware RE, Howard TA, Kamitani T, Change HM, Yeh ET, Seldin MF (Jul 1994). "Chromosomal assignment of genes involved in glycosylphosphatidylinositol anchor biosynthesis: implications for the pathogenesis of paroxysmal nocturnal hemoglobinuria". Blood. 83 (12): 3753–7. PMID 8204896.
^ "Entrez Gene: PIGH phosphatidylinositol glycan anchor biosynthesis, class H".
^ "AceView: Homo sapiens gene PIGH". AceView. National Library of Medicine. Retrieved 24 April 2011.
^ Watanabe, R; Inoue N; Westfall B; Taron C H; Orlean P; Takeda J; Kinoshita T (Feb 1998). "The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1". EMBO J. 17 (4). ENGLAND: 877–85. doi:10.1093/emboj/17.4.877. ISSN 0261-4189. PMC 1170437. PMID 9463366. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

Interactions

References

Further reading