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Protein-coding gene in the species Homo sapiens
Pirin is a protein that in humans is encoded by the PIR gene .[ 5] [ 6]
This gene encodes a member of the cupin superfamily . The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described.[ 6]
PIR (gene) has been shown to interact with BCL3 .[ 7]
The pir gene is conserved in both bacteria and eukaryotes. In Pseudomonas stutzeri [ 8] Streptomyces ambofaciens spiramycin , the pirA gene regulates the AcdB enzyme that catalyzes one of the first steps of beta-oxidation [ 9] pirA gene causes a metabolic imbalance that reduces the amount of antibiotic produced[ 9]
^ a b c GRCh38: Ensembl release 89: ENSG00000087842 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031379 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Wendler WM, Kremmer E, Forster R, Winnacker EL (May 1997). "Identification of pirin, a novel highly conserved nuclear protein" . J Biol Chem . 272 (13): 8482–9. doi :10.1074/jbc.272.13.8482 PMID 9079676 . ^ a b "Entrez Gene: PIR pirin (iron-binding nuclear protein)" .^ Dechend, R; Hirano F; Lehmann K; Heissmeyer V; Ansieau S; Wulczyn F G; Scheidereit C; Leutz A (Jun 1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators" . Oncogene . 18 (22): 3316–23. doi :10.1038/sj.onc.1202717 ISSN 0950-9232 . PMID 10362352 . ^ Widiatningrum, Talitha; Maeda, Sorato; Kataoka, Kunishige; Sakurai, Takeshi (2015-08-07). "A pirin-like protein from Pseudomonas stutzeri and its quercetinase activity" . Biochemistry and Biophysics Reports . 3 : 144–149. doi :10.1016/j.bbrep.2015.08.001 . ISSN 2405-5808 . PMC 5668851 PMID 29124178 . ^ a b Talà, Adelfia; Damiano, Fabrizio; Gallo, Giuseppe; Pinatel, Eva; Calcagnile, Matteo; Testini, Mariangela; Fico, Daniela; Rizzo, Daniela; Sutera, Alberto; Renzone, Giovanni; Scaloni, Andrea; De Bellis, Gianluca; Siculella, Luisa; De Benedetto, Giuseppe Egidio; Puglia, Anna Maria (July 2018). "Pirin: A novel redox-sensitive modulator of primary and secondary metabolism in Streptomyces" . Metabolic Engineering . 48 : 254–268. doi :10.1016/j.ymben.2018.06.008 . ISSN 1096-7184 . PMID 29944936 .
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Adams M, Jia Z (2005). "Structural and biochemical analysis reveal pirins to possess quercetinase activity" . J. Biol. Chem . 280 (31): 28675–82. doi :10.1074/jbc.M501034200 PMID 15951572 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway" . Genome Res . 14 (7): 1324–32. doi :10.1101/gr.2334104 . PMC 442148 PMID 15231748 . Pang H, Bartlam M, Zeng Q, et al. (2004). "Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor" . J. Biol. Chem . 279 (2): 1491–8. doi :10.1074/jbc.M310022200 PMID 14573596 . Zeng Q, Li X, Bartlam M, et al. (2004). "Purification, crystallization and preliminary X-ray analysis of human pirin". Acta Crystallogr. D . 59 (Pt 8): 1496–8. doi :10.1107/S0907444903012289 . PMID 12876364 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Dechend R, Hirano F, Lehmann K, et al. (1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators" . Oncogene . 18 (22): 3316–23. doi :10.1038/sj.onc.1202717 PMID 10362352 .
